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TDI-012804

TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids (EC50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids.

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  • CAS 番号: 3120102-92-0
  • 分子式: C30H26N4O4
  • 分子量:506.55
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • TDI-012804 Chemical Structure
    TDI-012804 構造式
CAS 番号: 3120102-92-0
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  • TDI-012804 Chemical Structure
    TDI-012804 Chemical Structure
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  • TDI-012804