country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-185443

Copy Link Print Information

UCP1172

UCP1172 is an antibacterial (Antibacterial) agent and Dihydrofolate reductase inhibitor, with an IC₅₀ of 0.0089 μM against Staphylococcus aureus DfrB, 0.22 μM against DfrG, 0.41 μM against DfrA, and 0.030 μM against DfrK. UCP1172 potently inhibits the growth of MRSA/MSSA isolates carrying dfrG and dfrK (MIC values of 0.3125-0.625 μg/mL), shows weak activity against MRSA carrying dfrA (MIC of 5 μg/mL), and exerts extremely potent inhibitory effects on wild-type S. aureus ATCC 43300 (MIC of 0.0098 μg/mL). UCP1172 can be used in studies related to tuberculosis and Staphylococcus aureus infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1922152-04-2
分子式: C₂₄H₂₄N₄O₃
分子量:416.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

UCP1172 構造式

CAS 番号: 1922152-04-2

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	100 μM Compound: 11R	Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay	[PMID: 27437079]

体外実験

UCP1172 (0.0098-5 μg/mL; 18 hr) potently inhibits the growth of dfrG- and dfrK-harboring MRSA/MSSA clinical isolates (MIC values 0.3125-0.625 μg/mL), shows weaker activity against dfrA-harboring MRSA (MIC 5 μg/mL), and highly potently inhibits wild-type S. aureus ATCC 43300 (MIC 0.0098 μg/mL)^[2].
UCP1172 (0.0089-0.41 μM) potently inhibits wild-type S. aureus DfrB (IC₅₀ 0.0089 μM) and TMP-resistant DfrG (IC₅₀ 0.22 μM), DfrA (IC₅₀ 0.41 μM), and DfrK (IC₅₀ 0.030 μM) DHFR enzymes, with drastically improved potency over TMP for the resistant variants^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1922152-04-2
分子量 416.47
分子式 C₂₄H₂₄N₄O₃
SMILES

CCC1=NC(N)=NC(N)=C1C#C[C@@H](C2=CC(OC)=CC(C3=CC=C(C=C3)C(O)=O)=C2)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ramharack P, et al. Dual-Target Mycobacterium tuberculosis Inhibition: Insights into the Molecular Mechanism of Antifolate Drugs. Int J Mol Sci. 2023 Sep 13;24(18):14021. [Content Brief]

[2]. Reeve SM, et al. MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol. 2016;23(12):1458-1467. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ