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Cat. No.: HY-115927

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8A8

8A8 is a potent proinflammatory factor NO inhibitor with an IC₅₀ of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation.

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CAS No.: 2766594-12-9
화학식: C₃₆H₃₇BrClN₅O₉
분자량:799.06

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

8A8 Chemical Structure

CAS No.: 2766594-12-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

8A8 is a potent proinflammatory factor NO inhibitor with an IC₅₀ of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation^[1].

All NO Synthase Isoforms :

In Vitro

Low concentrations of compound 8A8 (2.5 μM; RAW 264.7 cells) could significantly down-regulate IL-6 and TNF-α in cellular emotional intelligence, IL-6 and TNF-α are only half of those after LPS treatment at 5 μM, and IL-6 and TNF-α in cell supernatants were only a quarter of those after LPS treatment after high concentration compound 8A8 (10 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2766594-12-9
분자량 799.06
화학식 C₃₆H₃₇BrClN₅O₉
SMILES

COC1=CC(OC)=C2C(C(OCC3=CN(N=N3)CCN4CCN(CC4)C(C5=CC(Br)=CC=C5Cl)=O)=C(OC2=C1)C6=CC(OC)=C(C(OC)=C6)OC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang F, et al. Design and synthesis of the 4H-chromenone derivatives against psoriasis [published online ahead of print, 2022 Jan 25]. Bioorg Chem. 2022;120:105640. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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수량:
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8A8

All NO Synthase Isoforms