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Cat. No.: HY-10885

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A-620223 succinate

(Synonyms: ABT-472)

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

A-620223 succinate (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 succinate (ABT-472) exhibits very good potency against the PARP-1 enzyme with a K_i value of 8 nM and an EC₅₀ value of 3 nM in whole cell assay, making it useful in cancer research.

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CAS No.: 943650-25-7
화학식: C₂₀H₂₈N₄O₅
분자량:404.46

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

A-620223 succinate Chemical Structure

CAS No.: 943650-25-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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All PARP Isoforms :

Chemical Information

CAS No. 943650-25-7
분자량 404.46
화학식 C₂₀H₂₈N₄O₅
SMILES

CCCN(CC1)CCC1C2=NC3=C(C(N)=O)C=CC=C3N2.O=C(O)CCC(O)=O
Synonyms

ABT-472
선적

Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2025 Nov 10.

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Penning TD, et al. Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16(14):6965-75. [Content Brief]

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A-620223 succinate

1 Cited Publications

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A-620223 succinate

Publications Citing Use of MedChemExpress (MCE) A-620223 succinate

All PARP Isoforms

Biological Activity

Chemical Information

Publications (1)

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References

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A-620223 succinate Related Classifications

HY-10885 Related Classifications