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AGN-745

(Synonyms: AGN-211745; Sirna-027)

AGN-745 is a chemically modified siRNA targeted to VEGFR-1. It is used for the study of Macular degeneration.

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  • AGN-745 Chemical Structure
    AGN-745 Chemical Structure
CAS No.: 1255908-66-7
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All VEGFR Isoforms

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  • AGN-745 Chemical Structure
    AGN-745 Chemical Structure sense, 5'-BCUGAG UUU AAA AGG CAC CCT TB-3'; antisense,5'-GGG UGC CUU UUA AAC UCA GTST-3'. Modifications are unpaired deoxythymidines (T), one phosphorothioate linkage (s) and two inverted 2'-deoxy abasic nucleotides (B).
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  • sense, 5'-BCUGAG UUU AAA AGG CAC CCT TB-3'; antisense,5'-GGG UGC CUU UUA AAC UCA GTST-3'. Modifications are unpaired deoxythymidines (T), one phosphorothioate linkage (s) and two inverted 2'-deoxy abasic nucleotides (B).