Antitumor agent-170
Antitumor agent-170 (Compound C6) exhibits inhibitory activities against PD-1/PD-L1 interaction and PARP7, with IC50 of 0.342 μM and 7.05 nM. Antitumor agent-170 exhibits a high affinity to human PD-L1, with a Ki of 9.31 nM. Antitumor agent-170 restores the T cell function and increases IFN-γ secretion. Antitumor agent-170 exhibits antitumor efficacy against melanoma in mouse models and good pharmacokinetic characteristics.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C59H69ClF3N11O9
- 분자량:1168.70
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PARP7 7.05 nM (IC50) |
Chemical Information
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분자량 1168.70
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화학식 C59H69ClF3N11O9
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SMILES
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=C(C=C(C(OCC4=CN=CC=C4)=C3)CN5CCCC[C@H]5C(NCCOCCOCCNC(C6=CN=C(N=C6)N7CCN(CC7)C(CCOC[C@H](C)NC8=C(C(NN=C8)=O)C(F)(F)F)=O)=O)=O)Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-170 Related Classifications
HY-162644 Related Classifications
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