CDK1-IN-5
CDK1-IN-5 (10h) is a selective CDK1 inhibitor with IC50s of 42.19, 188.71 and 354.15 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-5 inhibits growth of cancer cells by affecting cell cycle. CDK1-IN-5 can be used for the research of cancer.
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- CAS No.: 3032997-20-6
- 화학식: C27H26ClN5OS
- 분자량:504.05
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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CDK1 42.19 nM (IC50) |
CDK2 188.71 nM (IC50) |
CDK5 354.15 nM (IC50) |
CDK1-IN-5 (0-10 μM; 24 h) inhibits the growth of various cancer cells[1]. CDK1-IN-5 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 42.19, 188.71 and 354.15 nM, respectively[1]. CDK1-IN-5 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 5649, 8945, 2538, 2417, 8546 and 8138 nM, respectively[1]. CDK1-IN-5 (0.73 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PDAC, melanoma, leukemia, colon, and breast cancer cell lines
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Concentration:0-10 μM
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Incubation Time:24 hours
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Result:Inhibited cell growth of PDAC, melanoma, leukemia, colon and breast cancer cells over 62%, and inhibited MDA-PATC53 and PL45 cells with IC50s of 0.73 and 1 μM, respectively.
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Cell Line:MDA-PATC53 cell line
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Concentration:0.73 μM
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Incubation Time:24 hours
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Result:Downregulated the CDK1 protein level compared to untreated cells.
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Cell Line:MDA-PATC53 cell line
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Concentration:0.73 μM
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Incubation Time:24 hours
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Result:Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.
Chemical Information
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CAS No. 3032997-20-6
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분자량 504.05
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화학식 C27H26ClN5OS
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SMILES
S=C(N1CCN(C2=NN=C(CC3=CC=C(OC)C=C3)C4=C2C=CC=C4)CC1)NC5=CC=CC(Cl)=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK1-IN-5 Related Classifications
HY-151409 Related Classifications
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