MCM2 - minichromosome maintenance complex component 2 Gene

Also Known as BM28; CCNL1; CDCL1; cdc19; DFNA70; D3S3194; MITOTIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4171

About MCM2

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,598,411-127,622,436 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 27.3), lymph node (RPKM 14.9) and 23 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of Other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

MCM2 Products (1)

mRNA	Protein	Name
NM_004526.4	NP_004517.2	DNA replication licensing factor MCM2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone binding	EXP EXP: Inferred from Experiment	25618846	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	25618846	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11095689	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication initiation	IMP IMP: Inferred from mutant phenotype	16899510	GOA
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	22474384	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	26196677	GOA
involved in cochlea development	IMP IMP: Inferred from mutant phenotype	26196677	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CMG complex	IPI IPI: Inferred from physical interaction	22474384	GOA
part of MCM complex	IDA IDA: Inferred from direct assay	17296731	GOA
part of MCM complex	IPI IPI: Inferred from physical interaction	22540012	GOA
located in chromatin	IDA IDA: Inferred from direct assay	16899510	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	26196677	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	21383955	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16899510	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA replication licensing factor MCM2	cell devision cycle-like 1

MCM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MCM2	P49736	AKAP8	Homo sapiens	O43823	Pull Down	12740381
Intra	MCM2	P49736	CENPA	Homo sapiens	P49450	Pull Down	26167883
Intra	MCM2	P49736	CENPA	Homo sapiens	P49450	Anti Tag CoIP	26167883
Intra	MCM2	P49736	GINS3	Homo sapiens	Q9BRX5	BiFC	19805216
Intra	MCM2	P49736	GINS3	Homo sapiens	Q9BRX5	Anti Tag CoIP	33961781
Intra	MCM2	P49736	H4C16	Homo sapiens	P62805	Pull Down	26167883
Intra	MCM2	P49736	H4C16	Homo sapiens	P62805	Anti Tag CoIP	26167883
Intra	MCM2	P49736	H4C16	Homo sapiens	P62805	Anti Bait CoIP	19862764
Intra	MCM2	P49736	DONSON	Homo sapiens	Q9NYP3	Anti Bait CoIP	32769987
Intra	MCM2	P49736	DONSON	Homo sapiens	Q9NYP3	PLA	32769987
Intra	MCM2	P49736	SSRP1	Homo sapiens	Q08945	Anti Tag CoIP	33961781
Intra	MCM2	P49736	MCM3	Homo sapiens	P25205	Pull Down	17296731
Intra	MCM2	P49736	MCM3	Homo sapiens	P25205	GMS	16899510
Intra	MCM2	P49736	MCM3	Homo sapiens	P25205	SLC	31467278
Intra	MCM2	P49736	MCM3	Homo sapiens	P25205	TAP	17296731
Intra	MCM2	P49736	MCM3	Homo sapiens	P25205	Density Sedimentation	22540012
Intra	MCM2	P49736	MCM3	Homo sapiens	P25205	Protein Array	15232106
Intra	MCM2	P49736	MCM3	Homo sapiens	P25205	Anti Tag CoIP	26167883
Intra	MCM2	P49736	MCM7	Homo sapiens	P33993	TAP	17296731
Intra	MCM2	P49736	MCM7	Homo sapiens	P33993	Pull Down	17296731
Intra	MCM2	P49736	MCM7	Homo sapiens	P33993	Anti Tag CoIP	33961781
Intra	MCM2	P49736	MCM7	Homo sapiens	P33993	GMS	16899510
Intra	MCM2	P49736	MCM7	Homo sapiens	P33993	Density Sedimentation	22540012
Intra	MCM2	P49736	MCM7	Homo sapiens	P33993	Protein Array	15232106
Intra	MCM2	P49736	MCM5	Homo sapiens	P33992	TAP	17296731
Intra	MCM2	P49736	MCM5	Homo sapiens	P33992	Density Sedimentation	22540012
Intra	MCM2	P49736	MCM5	Homo sapiens	P33992	Protein Array	15232106
Intra	MCM2	P49736	MCM5	Homo sapiens	P33992	GMS	16899510
Intra	MCM2	P49736	MCM5	Homo sapiens	P33992	Pull Down	17296731
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Pull Down	17296731
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Anti Tag CoIP	33961781
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Y2H Prey Pooling	25416956
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Y2H Array	25416956
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	TAP	17296731
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Density Sedimentation	22540012
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	GMS	16899510
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Anti Tag CoIP	26167883
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Anti Bait CoIP	17296731
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Y2H Pooling	16189514
Intra	MCM2	P49736	MCM6	Homo sapiens	Q14566	Y2H Array	20211142
Intra	MCM2	P49736	CDC45	Homo sapiens	O75419	Anti Tag CoIP	26167883
Intra	MCM2	P49736	CDC45	Homo sapiens	O75419	BiFC	19805216
Intra	MCM2	P49736	FANCM	Homo sapiens	Q8IYD8	PLA	32769987
Intra	MCM2	P49736	PLK1	Homo sapiens	P53350	CoIP	15654075
Intra	MCM2	P49736	SNF8	Homo sapiens	Q96H20	Pull Down	19819239
Intra	MCM2	P49736	SNF8	Homo sapiens	Q96H20	Y2H	19819239
Intra	MCM2	P49736	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	19819239
Intra	MCM2	P49736	MCMBP	Homo sapiens	Q9BTE3	Density Sedimentation	22540012
Intra	MCM2	P49736	MCMBP	Homo sapiens	Q9BTE3	Anti Tag CoIP	33961781
Intra	MCM2	P49736	ASF1A	Homo sapiens	Q9Y294	Anti Tag CoIP	26167883
Intra	MCM2	P49736	ASF1A	Homo sapiens	Q9Y294	Pull Down	26167883
Intra	MCM2	P49736	ASF1A	Homo sapiens	Q9Y294	Y2H Prey Pooling	32296183
Intra	MCM2	P49736	ASF1A	Homo sapiens	Q9Y294	Y2H Array	32296183
Intra	MCM2	P49736	ASF1A	Homo sapiens	Q9Y294	Anti Tag CoIP	33961781
Intra	MCM2	P49736	ASF1A	Homo sapiens	Q9Y294	Validated Y2H	32296183
Intra	MCM2	P49736	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	MCM2	P49736	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	MCM2	P49736	H3C1	Homo sapiens	P68431	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

MCM2 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P80215	MCM2 Antibody (YA302)	WB, IHC-P, ICC/IF, FC	Human
HY-P80749	MCM2 Antibody (YA705)	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse
HY-P810586	Phospho-MCM2 (Ser41) Antibody (YA9850)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
HY-P810587	Phospho-MCM2 (Ser108) Antibody (YA9851)	WB, IHC-P	Human, Mouse, Rat
HY-P810588	Phospho-MCM2 (Ser27) Antibody (YA9852)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
HY-P810589	Phospho-MCM2 (Ser40) Antibody (YA9853)	WB, ICC/IF, IHC-P, FC, IF-Tissue	Human, Mouse, Rat
HY-P85058	MCM2 Antibody (YA4750)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P85959	MCM2 Antibody (YA5651)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 70	DFNA70 Autosomal Dominant Nonsyndromic Deafness 70 Autosomal Dominant Deafness 70 Deafness, Autosomal Dominant, 70
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Deafness Type Dfna Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna Autosomal Dominant Isolated Sensorineural Deafness Type Dfna Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Cervix Endometriosis	Endometriosis Of Cervix Cervical Endometriosis
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Cardiomyopathy, Familial Hypertrophic, 6	Hypertrophic Cardiomyopathy 6 CMH6 Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome Cardiomyopathy, Familial Hypertrophic 6 Cardiomyopathy, Hypertrophic 6 Cardiomyopathy, Hypertrophic, Familial, Type 6
Immunodeficiency 7	Tcr-Alpha-Beta-Positive T-Cell Deficiency IMD7 T-Cell Receptor-Alpha/Beta Deficiency Immunodeficiency 7, Tcr-Alpha/Beta Deficient Tcr-Alpha/Beta Deficiency Tcr-Alpha-Beta+ T-Cell Deficiency T-Cell Receptor Alpha/Beta Deficiency
Barrett Esophagus	Barrett'S Esophagus Barrett Esophagus/Esophageal Adenocarcinoma Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Familial Glucocorticoid Deficiency	Glucocorticoid Deficiency Acth Resistance Adrenal Unresponsiveness To Acth Hereditary Unresponsiveness To Adrenocorticotropic Hormone Isolated Glucocorticoid Deficiency Glucocorticoid Deficiency, Familial Glucocorticoid Deficiency 1
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-143432A	(S)-Cdc7-IN-18	Inhibitor	/	Unkown
HY-RS08234	MCM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08240	MCM7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17409	Mcm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23863	Mcm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MCM2	RGD	RGD:1305577
Mus musculus	MCM2	MGD	MGI:105380
Canis familiaris	MCM2	VGNC	VGNC:43081
Bos taurus	MCM2	VGNC	VGNC:31308
Felis catus	MCM2	VGNC	VGNC:68212
Macaca mulatta	MCM2	VGNC	VGNC:74680
Others	MCM2	NCBI