GINS3 - GINS complex subunit 3 Gene

Also Known as PSF3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64785

About GINS3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,392,471-58,406,147 (from NCBI)

This gene has 10 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in lymph node (RPKM 4.0), testis (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GINS3 Products (3)

mRNA Protein Name
NM_001126129.2 NP_001119601.1 DNA replication complex GINS protein PSF3 isoform a
NM_001126130.2 NP_001119602.1 DNA replication complex GINS protein PSF3 isoform c
NM_022770.4 NP_073607.2 DNA replication complex GINS protein PSF3 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19805216 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA unwinding involved in DNA replication IDA
IDA: Inferred from direct assay
22474384 GOA
Cellular Component GO Annotation Evidence References Source
part of CMG complex IPI
IPI: Inferred from physical interaction
22474384 GOA
part of GINS complex IPI
IPI: Inferred from physical interaction
17417653 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22474384 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GINS3 Protein Structure

Sld5

Sld5: GINS complex protein (67 - 173)

  • 0
  • 100
  • 200
  • 216 a.a.
Protein Preferred Names Protein Names

DNA replication complex GINS protein PSF3

  • GINS complex subunit 3 (Psf3 homolog)

GINS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GINS3 Q9BRX5 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
26871637
Intra
GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Validated Y2H
26871637
Intra
GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Y2H Array
26871637
Intra
GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
GINS3 Q9BRX5 ICAM5 Homo sapiens Q9UMF0
Validated Y2H
32814053
Intra
GINS3 Q9BRX5 ICAM5 Homo sapiens Q9UMF0
Y2H Array
32814053
Intra
GINS3 Q9BRX5 ICAM5 Homo sapiens Q9UMF0
Y2H Pooling
32814053
Intra
GINS3 Q9BRX5 UQCRB Homo sapiens P14927
Validated Y2H
32814053
Intra
GINS3 Q9BRX5 UQCRB Homo sapiens P14927
Y2H Pooling
32814053
Intra
GINS3 Q9BRX5 UQCRB Homo sapiens P14927
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adrenal Cortical Adenocarcinoma

  • Adrenal Cortex Adenocarcinoma

  • Adrenocortical Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05432 GINS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GINS3 VGNC VGNC:62555
Rattus norvegicus GINS3 RGD RGD:1308153
Mus musculus GINS3 MGD MGI:1926083
Bos taurus GINS3 VGNC VGNC:29362
Canis familiaris GINS3 VGNC VGNC:41222
Macaca mulatta GINS3 VGNC VGNC:73014
Others GINS3 NCBI