country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182455

Copy Link Print Information

GSK3527497

GSK3527497 is an orally active TRPV4 inhibitor. GSK3527497 is applicable for the research of heart failure.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2215855-22-2
화학식: C₁₇H₁₆ClFN₄O₄S
분자량:426.85

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSK3527497 Chemical Structure

CAS No.: 2215855-22-2

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

GSK3527497 is an orally active TRPV4 inhibitor. GSK3527497 is applicable for the research of heart failure^[1].

IC₅₀ & Target^[1]

TRPV4

All TRP Channel Isoforms :

In Vitro

GSK3527497 potently inhibits hTRPV4 with an IC₅₀ of 12 nM in a FLIPR assay^[1].
GSK3527497 inhibits hERG with an IC₅₀ of 20 μM^[1].
GSK3527497 inhibits CYP3A4 with an IC₅₀ of 12 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	MRT	CL	V_dss	F
Rat^[1]	1 mg/kg	i.v.	2.5 h	45 mL/min/kg	6.7 L/kg	/
Rat^[1]	2 mg/kg	p.o.	/	/	/	26 %
Rat^[1]	100 mg/kg	p.o.	/	/	/	87 %

Chemical Information

CAS No. 2215855-22-2
분자량 426.85
화학식 C₁₇H₁₆ClFN₄O₄S
SMILES

NC[C@](O)(CN(C1)S(=O)(C2=CC=C(C=N2)Cl)=O)[C@H]1OC3=CC(F)=C(C=C3)C#N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Brooks CA, et al. Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4). J Med Chem. 2019;62(20):9270-9280. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

GSK3527497

All TRP Channel Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GSK3527497 Related Classifications

HY-182455 Related Classifications