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Cat. No.: HY-150500

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HDAC-IN-44

HDAC-IN-44 is a HDAC inhibitor with the IC₅₀ value of 61.2 nM.
HDAC-IN-44 shows high anticancer activity towards multiple cancer cell lines.

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CAS No.: 2414921-46-1
화학식: C₂₆H₂₇BrN₄O₄
분자량:539.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HDAC-IN-44 Chemical Structure

CAS No.: 2414921-46-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HDAC-IN-44 is a HDAC inhibitor with the IC₅₀ value of 61.2 nM.
HDAC-IN-44 shows high anticancer activity towards multiple cancer cell lines^[1].

All HDAC Isoforms :

In Vitro

HDAC-IN-44 (20 µg/mL; 24 h) treatment shows inhibitory effects on acute lymphoblastic leukemia (Molt 4 cells), T-cell lymphoblastic lymphoma (Sup-T1 cells), chronic myelogenous leukemia (K562 cells), gastric adenocarcinoma (AGS), prostate cancer (PC3 and LNCaP cells) and breast cancer (T47D cells) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:

Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D cells^[1]
Concentration:

20 µg/mL
Incubation Time:

24 hours
Result:

Exhibited IC₅₀ values of 11, 9.1, 16.3, 7.1, 13.4, 32.7 and 9.2 μM in Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D cells, respectively^[1].

Chemical Information

CAS No. 2414921-46-1
분자량 539.42
화학식 C₂₆H₂₇BrN₄O₄
SMILES

O=C(NO)CCCCCN(C1)C([C@]2([H])CC3=C([C@H](C4=CC=C(Br)C=C4)N2C1=O)NC5=C3C=CC=C5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahmed K ElHady et al. Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103742. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
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수량:
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HDAC-IN-44

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HDAC-IN-44 Related Classifications

HY-150500 Related Classifications