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Cat. No.: HY-163143

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HDAC8-IN-6

HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC₅₀ of 5.1 μM. HDAC8-IN-6 shows cytotoxicity.

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CAS No.: 3036403-81-0
화학식: C₁₉H₁₈IN₃O₂
분자량:447.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HDAC8-IN-6 Chemical Structure

CAS No.: 3036403-81-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC₅₀ of 5.1 μM. HDAC8-IN-6 shows cytotoxicity^[1].

IC₅₀ & Target^[1]

HDAC8

5.1 μM (IC₅₀)

HDAC4

23.1 μM (IC₅₀)

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	IC₅₀	>200 μM Compound: 3	Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
HL-60	IC₅₀	161 μM Compound: 3	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
MOLM-13	IC₅₀	7.08 μM Compound: 3	Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
MV4-11	IC₅₀	8.23 μM Compound: 3	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
OCI-AML-3	IC₅₀	27.17 μM Compound: 3	Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
SET-2	IC₅₀	>200 μM Compound: 3	Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
THP-1	IC₅₀	46.5 μM Compound: 3	Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]

Chemical Information

CAS No. 3036403-81-0
분자량 447.27
화학식 C₁₉H₁₈IN₃O₂
SMILES

C[N+]1=CC=C(NC(CC(N2CC3=C(C=CC=C3)C2)=O)=O)C(C#C)=C1.[I-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Keeley AB, et al. Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors. J Med Chem. 2024 Jan 11;67(1):572-585. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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HDAC8-IN-6

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HDAC8-IN-6 Related Classifications

HY-163143 Related Classifications