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Cat. No.: HY-167664

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KY-455

KY-455 is a novel inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). KY-455 inhibita rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC₅₀ values of 0.4, 0.9, 2.9 and 4.1 μmol/L, respectively.

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CAS No.: 178469-71-1
화학식: C₂₀H₃₂N₂O
분자량:316.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

KY-455 Chemical Structure

CAS No.: 178469-71-1

사이즈

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Acyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	IC₅₀	0.51 μM Compound: 3e	Anti-foam cell formation activity in human THP1 cells assessed as inhibition of esterified cholesterol accumulation after 24 hrs in presence of Japanese white rabbit high-cholesterol serum Anti-foam cell formation activity in human THP1 cells assessed as inhibition of esterified cholesterol accumulation after 24 hrs in presence of Japanese white rabbit high-cholesterol serum	[PMID: 19608421]

Chemical Information

CAS No. 178469-71-1
분자량 316.48
화학식 C₂₀H₃₂N₂O
SMILES

O=C(C(C)(C)C)NC1=C(C)C=C(C)C2=C1N(CCCCC)CC2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shohei Nakamura, et al. Hypolipidemic and antioxidant activity of the novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor KY-455 in rabbits and hamsters. Arzneimittelforschung. 2004;54(2):102-8. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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KY-455

All Acyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KY-455 Related Classifications

HY-167664 Related Classifications