Methyl arachidonate
Based on 1 Customer Validation
Methyl arachidonate is a protein kinase C activator and also an orally active substrate that undergoes esterase-mediated hydrolysis. Methyl arachidonate indirectly activates protein kinase C via eicosanoid metabolites generated through the arachidonic acid metabolic pathway, exerting effects via cyclooxygenase products at low concentrations and via lipoxygenase products at high concentrations. Methyl arachidonate can be used in studies related to lipodystrophy.
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- Purity: 99.9%
- CAS No.: 2566-89-4
- 화학식: C21H34O2
- 분자량:318.49
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보관:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Methyl arachidonate (50 μM; 5 min) is poorly active in activating purified rat brain protein kinase C in a phosphatidylserine- and calcium-free in vitro assay, inducing less than 20% of maximal activation[1].
Methyl arachidonate (1-500 μM; 10 s-3 min) potently activates protein kinase C in intact human platelets in vitro in a concentration- and time-dependent manner, with maximal activation (101.0% of TPA control) at 500 μM for 1 min, and activation is mediated by eicosanoid metabolites, as shown by inhibition by cyclooxygenase and lipoxygenase inhibitors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain (mixed sex, weanling age)[2]
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Dosage:42 mg daily; 14 mg daily; 14 mg every 2nd day; 14 mg every 4th day
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Administration:p.o.; 35 days
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Result:Achieved an average total weight increase of 15 g over 35 days (42 mg daily).
Achieved an average total weight increase of 21-28 g over 35 days (14 mg daily), with greater total weight increase than less frequent dosing groups in the 12 days post-treatment.
Achieved an average total weight increase of 14 g over 35 days (14 mg every 2nd day).
Achieved an average total weight increase of 4 g over 35 days (14 mg every 4th day).
Produced partial to complete healing of ankle skin lesions (42 mg daily).
Chemical Information
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CAS No. 2566-89-4
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Appearance Liquid
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분자량 318.49
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화학식 C21H34O2
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Color White to light yellow
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OC)=O
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Synonyms
Arachidonic acid methyl ester
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Solution, -20°C, 2 years
용액&용해도
DMSO : 100 mg/mL (313.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
순도&문서
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Data Sheet (265 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Handling Instructions (2659 KB)
References
[1]. Fan XT, et al. Arachidonic acid and related methyl ester mediate protein kinase C activation in intact platelets through the arachidonate metabolism pathways. Biochem Biophys Res Commun. 1990;169(3):933-940. [Content Brief]
[2]. Hume EM, et al. Fat-deficiency disease of rats. The relative curative potencies of methyl linoleate and methyl arachidonate with a note on the action of the methyl esters of fatty acids from cod liver oil. Biochem J. 1940 Jun;34(6):879-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1398 mL | 15.6991 mL | 31.3982 mL | 78.4954 mL |
| 5 mM | 0.6280 mL | 3.1398 mL | 6.2796 mL | 15.6991 mL | |
| 10 mM | 0.3140 mL | 1.5699 mL | 3.1398 mL | 7.8495 mL | |
| 15 mM | 0.2093 mL | 1.0466 mL | 2.0932 mL | 5.2330 mL | |
| 20 mM | 0.1570 mL | 0.7850 mL | 1.5699 mL | 3.9248 mL | |
| 25 mM | 0.1256 mL | 0.6280 mL | 1.2559 mL | 3.1398 mL | |
| 30 mM | 0.1047 mL | 0.5233 mL | 1.0466 mL | 2.6165 mL | |
| 40 mM | 0.0785 mL | 0.3925 mL | 0.7850 mL | 1.9624 mL | |
| 50 mM | 0.0628 mL | 0.3140 mL | 0.6280 mL | 1.5699 mL | |
| 60 mM | 0.0523 mL | 0.2617 mL | 0.5233 mL | 1.3083 mL | |
| 80 mM | 0.0392 mL | 0.1962 mL | 0.3925 mL | 0.9812 mL | |
| 100 mM | 0.0314 mL | 0.1570 mL | 0.3140 mL | 0.7850 mL |
Methyl arachidonate Related Classifications
HY-W011297 Related Classifications
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