Spisulosine
Based on 1 Customer Validation
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells.
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- Purity: 99.5%
- CAS No.: 196497-48-0
- 화학식: C18H39NO
- 분자량:285.51
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PKCζ |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HBL-100 | GI50 |
2.3 μM
Compound: 1
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Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay
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[PMID: 25899335] |
| HCT-116 | IC50 |
100 nM
Compound: 3; ES-285
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Cytotoxicity against human HCT-116 cell
Cytotoxicity against human HCT-116 cell
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[PMID: 31926468] |
| HeLa | GI50 |
2.6 μM
Compound: 1
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Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay
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[PMID: 25899335] |
| HL-60 | IC50 |
100 nM
Compound: 3; ES-285
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Cytotoxicity against human HL-60 cell
Cytotoxicity against human HL-60 cell
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[PMID: 31926468] |
| KB | IC50 |
100 nM
Compound: 3; ES-285
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Cytotoxicity against human KB cell
Cytotoxicity against human KB cell
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[PMID: 31926468] |
| LNCaP | IC50 |
1 μM
Compound: 3; ES-285
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Cytotoxicity against human LNCaP cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human LNCaP cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31926468] |
| PC-3 | IC50 |
1 μM
Compound: 3; ES-285
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31926468] |
| SW1573 | GI50 |
1.3 μM
Compound: 1
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Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay
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[PMID: 25899335] |
| T47D | GI50 |
0.9 μM
Compound: 1
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Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay
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[PMID: 25899335] |
| WiDr | GI50 |
0.7 μM
Compound: 1
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Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay
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[PMID: 25899335] |
Spisulosine (1 nM-10 μM; 48 h) inhibits the growth of prostate tumor PC-3 and LNCaP cells and human prostate epithelial RWPE-1 cells, and is more effective in PC-3 cells[1].
Spisulosine (1 μM; 48 h) affects the cell cycle, with an increase in the number of sub-G1 cells[1].
Spisulosine (1 μM) induces apoptosis and enhances cleavage of procaspase-3 in PC-3 and LNCaP cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3, LNCaP and RWPE-1 cells
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Concentration:1 nM, 10 nM, 100 nM, 1 μM 10 μM
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Incubation Time:48 h
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Result:Significantly decreased cell viability.
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Cell Line:PC-3, LNCaP and RWPE-1 cells
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Concentration:1 μM
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Incubation Time:48 h
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Result:Showed an increase in the number of sub-G1 cells.
Chemical Information
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CAS No. 196497-48-0
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Appearance Solid
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분자량 285.51
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화학식 C18H39NO
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Color White to off-white
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SMILES
C[C@H](N)[C@H](O)CCCCCCCCCCCCCCC
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Synonyms
ES-285
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 2 mg/mL (7.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5025 mL | 17.5125 mL | 35.0250 mL | 87.5626 mL |
| 5 mM | 0.7005 mL | 3.5025 mL | 7.0050 mL | 17.5125 mL |
Spisulosine Related Classifications
HY-13626 Related Classifications
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