Terbinafine lactate
Based on 18 publication(s) in Google Scholar
Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- CAS No.: 335276-86-3
- 화학식: C24H31NO3
- 분자량:381.51
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Terbinafine lactate
More- Cancer Commun (Lond). 2021 Aug;41(8):726-746. [Abstract]
- Cancer Res. 2022 Sep 2;82(17):3032-3044. [Abstract]
- Nat Microbiol. 2024 Feb;9(2):346-358. [Abstract]
- Autophagy. 2025 Oct;21(10):2266-2283. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(19):e08588. [Abstract]
- Adv Sci (Weinh). 2023 Sep;10(27):e2206878. [Abstract]
- Cell Death Dis. 2021 May 13;12(5):482. [Abstract]
- Cancer Lett. 2025 Oct 10:630:217901. [Abstract]
- Adv Healthc Mater. 2023 Sep;12(22):e2300018. [Abstract]
- Int J Biol Macromol. 2026 Apr:354:151416. [Abstract]
- Clin Transl Med. 2024 Feb;14(2):e1586. [Abstract]
- Probiotics Antimicrob Proteins. 2026 Jan 6. [Abstract]
- J Orthop Surg Res. 2025 Oct 17;20(1):894. [Abstract]
- Infect Drug Resist. 2022 Dec 15:15:7459-7473. [Abstract]
- bioRxiv. 2026 Apr 3.
- University of Szeged. 2026.
- bioRxiv. 2024 May 14.
- Research Square Preprint. 2023 Sep 26.
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
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IHC
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Biological Activity
Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation. The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 335276-86-3
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분자량 381.51
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화학식 C24H31NO3
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SMILES
CC(O)C(O)=O.CN(C/C=C/C#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1
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Synonyms
TDT 067 lactate
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (18)
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Journal Impact Factor
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Most Recent
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Cancer Commun (Lond)
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. [Abstract]2021 Aug;41(8):726-746. PMID: 34268906
Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746. [Abstract]
Cell viabilities of CRC cell lines treated with Terbinafine at 10, 25, 50 μmol/L were accessed by CCK8 assay. DMSO was used as control.
Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746. [Abstract]
Colony formation of CRC cell lines treated with Terbinafine at 50 μmol/L. DMSO was used as control.
Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746. [Abstract]
Cell cycle analysis (G0/G1, S, G2/M phase) of HT29 cells treated with terbinafine at 10, 25, 50 μmol/L. DMSO was used as control.
Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746. [Abstract]
Intracellular cholesterol levels of HT29 or RKO cells treated with Terbinafine at 10, 25, 50 μmol/L were accessed by cholesterol measurement. DMSO was used as control.
Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746. [Abstract]
IHC analysis of Ki67 in HT29 and RKO cells‐derived xenograft tumors and treated with terbinafine (oral, 50 mg/kg).
Terbinafine lactate purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Aug;41(8):726-746. [Abstract]
Tumor growth curve of RKO cells treated with terbinafine (oral, 50 mg/kg) in nude mice.
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Cancer Res
Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer. [Abstract]2022 Sep 2;82(17):3032-3044. PMID: 35767703 -
Nat Microbiol
Brain glucose induces tolerance of Cryptococcus neoformans to amphotericin B during meningitis. [Abstract]2024 Feb;9(2):346-358. PMID: 38225460 -
Autophagy
MoSec13 combined with MoGcn5b modulates MoAtg8 acetylation and regulates autophagy in Magnaporthe oryzae. [Abstract]2025 Oct;21(10):2266-2283. PMID: 40320672 -
Adv Sci (Weinh)
Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression. [Abstract]2026 Apr;13(19):e08588. PMID: 41603134 -
Adv Sci (Weinh)
Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC. [Abstract]2023 Sep;10(27):e2206878. PMID: 37490552 -
Cell Death Dis
Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma. [Abstract]2021 May 13;12(5):482. PMID: 33986254 -
Cancer Lett
PD-L1 delactylation-promoted nuclear translocation accelerates liver cancer growth through elevating SQLE transcription activity. [Abstract]2025 Oct 10:630:217901. PMID: 40614853 -
Adv Healthc Mater
Cholesterol Metabolism Modulation Nanoplatform Improves Photo-Immunotherapeutic Effect In Oral Squamous Cell Carcinoma. [Abstract]2023 Sep;12(22):e2300018. PMID: 37209373 -
Int J Biol Macromol
Bletilla striata polysaccharide alleviates obesity by remodeling the gut microbiota-metabolite-liver axis and suppressing the hepatic AMPK-SREBP2/SQLE signaling pathway. [Abstract]2026 Apr:354:151416. PMID: 41833674 -
Clin Transl Med
Identifying squalene epoxidase as a metabolic vulnerability in high-risk osteosarcoma using an artificial intelligence-derived prognostic index. [Abstract]2024 Feb;14(2):e1586. PMID: 38372422 -
Probiotics Antimicrob Proteins
Screening the γ-core Motif Peptides of Ascomycetous Antifungal Proteins for Antifungal Activity and Potential Therapeutic Applicability. [Abstract]2026 Jan 6. PMID: 41493708 -
J Orthop Surg Res
Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study. [Abstract]2025 Oct 17;20(1):894. PMID: 41107894 -
Infect Drug Resist
Correlation Between Drug Resistance and Virulence of Candida Isolates from Patients with Candidiasis. [Abstract]2022 Dec 15:15:7459-7473. PMID: 36544991 -
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순도&문서
References
[1]. Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-8. [Content Brief]
[2]. Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-8. [Content Brief]
[3]. Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69(8):679-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Terbinafine lactate Related Classifications
HY-17395B Related Classifications
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