2. Academic Validation
  3. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities

Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities

  • J Antibiot (Tokyo). 1992 Sep;45(9):1414-9. doi: 10.7164/antibiotics.45.1414.
H Takahashi 1,  H Osada,  H Koshino,  M Sasaki,  R Onose,  M Nakakoshi,  M Yoshihama,  K Isono
Affiliations

Affiliation

  • 1 Antibiotics Laboratory, RIKEN, Institute of Physical and Chemical Research, Saitama, Japan.
PMID: 1429226 DOI: 10.7164/antibiotics.45.1414
Abstract

Reveromycins A, B, C and D showed inhibitory activity against EGF-stimulated mitogen response in Balb/MK cells. Furthermore reveromycins A, C and D exhibited morphological reversion of srcts-NRK cells, antiproliferative activity against human tumor cell lines and Antifungal activity. The effects of reveromycins A, C and D on eukaryotic cells were closely similar to each other, but those of reveromycin B were very weak. In vitro studies revealed that reveromycin A is a selective inhibitor of protein synthesis in eukaryotic cells.

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