2. Academic Validation
  3. Small-molecule WNK inhibition regulates cardiovascular and renal function

Small-molecule WNK inhibition regulates cardiovascular and renal function

  • Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168.
Ken Yamada 1,  Hyi-Man Park 1,  Dean F Rigel 1,  Keith DiPetrillo 1,  Erin J Whalen 1,  Anthony Anisowicz 1,  Michael Beil 1,  James Berstler 1,  Cara Emily Brocklehurst 1,  Debra A Burdick 1,  Shari L Caplan 1,  Michael P Capparelli 1,  Guanjing Chen 1,  Wei Chen 1,  Bethany Dale 1,  Lin Deng 1,  Fumin Fu 1,  Norio Hamamatsu 1,  Kouki Harasaki 1,  Tracey Herr 1,  Peter Hoffmann 1,  Qi-Ying Hu 1,  Waan-Jeng Huang 1,  Neeraja Idamakanti 1,  Hidetomo Imase 1,  Yuki Iwaki 1,  Monish Jain 1,  Jey Jeyaseelan 1,  Mitsunori Kato 1,  Virendar K Kaushik 1,  Darcy Kohls 1,  Vidya Kunjathoor 1,  Daniel LaSala 1,  Jongchan Lee 1,  Jing Liu 1,  Yang Luo 1,  Fupeng Ma 1,  Ruowei Mo 1,  Sarah Mowbray 1,  Muneto Mogi 1,  Flavio Ossola 1,  Pramod Pandey 1,  Sejal J Patel 1,  Swetha Raghavan 1,  Bahaa Salem 1,  Yuka H Shanado 1,  Gary M Trakshel 1,  Gordon Turner 1,  Hiromichi Wakai 1,  Chunhua Wang 1,  Stephen Weldon 1,  Jennifer B Wielicki 1,  Xiaoling Xie 1,  Lingfei Xu 1,  Yukiko I Yagi 1,  Kayo Yasoshima 1,  Jianning Yin 1,  David Yowe 1,  Ji-Hu Zhang 1,  Gang Zheng 1,  Lauren Monovich 1
Affiliations

Affiliation

  • 1 Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
PMID: 27595330 DOI: 10.1038/nchembio.2168
Abstract

The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-WNK-kinase inhibitor, WNK463, that exploits unique structural features of the WNK kinases for both affinity and kinase selectivity. In rodent models of hypertension, WNK463 affects blood pressure and body fluid and electro-lyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology.

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