NF-κB-IN-12
NF-κB-IN-12 (compound 3h) is a potent NF-κB inhibitor, with an IC50 of 1.02 μM. NF-κB-IN-12 can be used for acute lung injury research.
For research use only. We do not sell to patients.
- Formula: C30H26N6O5S
- Molecular Weight:582.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.02 ± 0.29 μM (NF-κB)[1]
NF-κB-IN-12 (compound 3h) is non-toxic to MCF-12A cells (normal epithelial cells)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (SD) rats (male, 7-9 weeks old, weighing 210-260 g)[1]
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Dosage:5, 10 mg/kg
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Administration:IP, daily for 3 days before CLP surgery and on the 4th day 1 h before CLP
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Result:Significantly upregulated SOD and GSH. Improved the antioxidant status of experimental rats. Reduced the elevated level of nuclear NF-ĸB. Caused a significant reduction in lung edema and total proteins, mononuclear leukocytes, and polymorphonuclear leukocytes in BALF (bronchoalveolar lavage fluid).
Chemical Information
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Molecular Weight 582.63
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Formula C30H26N6O5S
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SMILES
O=C(N1N=CC(C2=CC=C(S(=O)(C3=CC=C(O)C=C3)=O)C=C2)C1C4=CC=C(OC)C=C4)C5=CN6C(C(NC)=NC=C6)=N5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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