2. NF-κB
  3. NF-κB
  4. NF-κB-IN-12

NF-κB-IN-12 (compound 3h) is a potent NF-κB inhibitor, with an IC50 of 1.02 μM. NF-κB-IN-12 can be used for acute lung injury research.

For research use only. We do not sell to patients.

NF-κB-IN-12 Chemical Structure

NF-κB-IN-12 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

NF-κB-IN-12 Related Antibodies

Top Publications Citing Use of Products

View All NF-κB Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NF-κB-IN-12 (compound 3h) is a potent NF-κB inhibitor, with an IC50 of 1.02 μM. NF-κB-IN-12 can be used for acute lung injury research[1].

IC50 & Target

IC50: 1.02 ± 0.29 μM (NF-κB)[1]
In Vitro

NF-κB-IN-12 (compound 3h) is non-toxic to MCF-12A cells (normal epithelial cells)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-12 Related Antibodies
In Vivo

NF-κB-IN-12 (compound 3h) (5-10 mg/kg, IP, daily) shows a protective effect in SD rats against sepsis induced by the CLP (cecal ligation puncture) method[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) rats (male, 7-9 weeks old, weighing 210-260 g)[1]
Dosage: 5, 10 mg/kg
Administration: IP, daily for 3 days before CLP surgery and on the 4th day 1 h before CLP
Result: Significantly upregulated SOD and GSH. Improved the antioxidant status of experimental rats. Reduced the elevated level of nuclear NF-ĸB. Caused a significant reduction in lung edema and total proteins, mononuclear leukocytes, and polymorphonuclear leukocytes in BALF (bronchoalveolar lavage fluid).
Molecular Weight

582.63

Formula

C30H26N6O5S
SMILES

O=C(N1N=CC(C2=CC=C(S(=O)(C3=CC=C(O)C=C3)=O)C=C2)C1C4=CC=C(OC)C=C4)C5=CN6C(C(NC)=NC=C6)=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

NF-κB-IN-12 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-12NF-κBNuclear factor-κBNuclear factor-kappaBMCF-12Aanti-inflammatorysepsisacute lung injuryInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
NF-κB-IN-12
Cat. No.:
HY-149580
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.