Sodium 4-phenylbutyrate
Based on 240 publication(s) in Google Scholar
Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 1716-12-7
- Formula: C10H11NaO2
- Molecular Weight:186.18
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
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Publications Citing Use of MedChemExpress (MCE) Sodium 4-phenylbutyrate
More- Science. 2026 Feb 26;391(6788):eads4405. [Abstract]
- Cell. 2025 Aug 7;188(16):4441-4455.e16. [Abstract]
- Bioact Mater. 2023 Apr 14:27:257-270. [Abstract]
- Nat Cell Biol. 2024 Nov;26(11):1892-1902. [Abstract]
- Sci Immunol. 2023 Sep 29;8(87):eabq2424. [Abstract]
- Nat Commun. 2025 Aug 29;16(1):8074. [Abstract]
- Acta Pharm Sin B. 2024 Aug;14(8):3493-3512. [Abstract]
- Acta Pharm Sin B. 2022 May;12(5):2315-2329. [Abstract]
- Autophagy. 2022 Oct;18(10):2350-2367. [Abstract]
- Autophagy. 2021 Nov;17(11):3592-3606. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(21):e14863. [Abstract]
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- Cell Mol Biol Lett. 2023 Oct 12;28(1):79. [Abstract]
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- Cancer Lett. 2022 Feb 1:526:352-362. [Abstract]
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- Cell Mol Neurobiol. 2025 May 29;45(1):53. [Abstract]
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- Am J Physiol Cell Physiol. 2025 Mar 1;328(3):C1076-C1089. [Abstract]
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- Int Immunopharmacol. 2022 Feb:103:108489. [Abstract]
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- Biosci Rep. 2019 Aug 7;39(8):BSR20190578. [Abstract]
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- J Dairy Sci. 2023 Jul;106(7):5146-5164. [Abstract]
- Mol Neurobiol. 2025 May 26. [Abstract]
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- Mediators Inflamm. 2026 Jan 22:2026:5595023. [Abstract]
- FASEB J. 2025 Nov 30;39(22):e71250. [Abstract]
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- Lipids Health Dis. 2025 Apr 12;24(1):138. [Abstract]
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- Lipids Health Dis. 2025 Feb 11;24(1):44. [Abstract]
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- Exp Neurol. 2024 May:375:114738. [Abstract]
- Lab Invest. 2022 Nov;102(11):1192-1202. [Abstract]
- J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [Abstract]
- Neurooncol Adv. 2026 Feb 13.
- J Lipid Res. 2024 Nov 4:100692. [Abstract]
- Nutr Metab. 2020 Jan 30;17:11. [Abstract]
- Toxins. 2024 Oct 9;16(10):432. [Abstract]
- J Funct Foods. 2024 Apr, 115, 106102.
- J Funct Foods. 2022, 99: 105336.
- J Funct Foods. 2020, 104178.
- Biomedicines. 2025 Aug 6;13(8):1919. [Abstract]
- Sci Rep. 2025 May 5;15(1):15659. [Abstract]
- Fish Shellfish Immunol. 2024 Nov 9:155:110020. [Abstract]
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- Sci Rep. 2023 Nov 9;13(1):19438. [Abstract]
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- Sci Rep. 2023 Jan 20;13(1):1147. [Abstract]
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- Neurochem Res. 2026 Feb 7;51(1):66. [Abstract]
- Cell Signal. 2025 Jul:131:111753. [Abstract]
- Vet Res. 2025 Jul 15;56(1):150. [Abstract]
- Vet Res. 2024 Jun 14;55(1):78. [Abstract]
- Mol Med Rep. 2024 May;29(5):71. [Abstract]
- J Neuroimmune Pharmacol. 2024 Jan 12;19(1):1. [Abstract]
- Food Chem Toxicol. 2023 Oct:180:114033. [Abstract]
- Vet Res. 2023 Mar 22;54(1):27. [Abstract]
- Viruses. 2023 Feb 14;15(2):534. [Abstract]
- Food Chem Toxicol. 2022 Aug:166:113263. [Abstract]
- Food Chem Toxicol. 2020 Jun;140:111329. [Abstract]
- Food Chem Toxicol. 2020 Feb;136:111080. [Abstract]
- BMC Complement Med Ther. 2024 Nov 16;24(1):400. [Abstract]
- BMC Complement Med Ther. 2022 May 5;22(1):125. [Abstract]
- Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Aug 21:159559. [Abstract]
- Chem Biol Drug Des. 2024 Jan;103(1):e14433. [Abstract]
- Front Oncol. 2021 Oct 27;11:722624. [Abstract]
- Front Oncol. 2021 Jul 7;11:663600. [Abstract]
- Pathol Res Pract. 2026 Jun:282:156442. [Abstract]
- Pathol Res Pract. 2026 May:281:156400. [Abstract]
- Mol Carcinog. 2024 Sep;63(9):1783-1799. [Abstract]
- Int J Med Sci. 2024 Jan 1;21(2):341-356. [Abstract]
- Environ Toxicol. 2023 Aug;38(8):1874-1890. [Abstract]
- Cell Stress Chaperones. 2023 Jan;28(1):49-60. [Abstract]
- Cell Stress Chaperones. 2022 May;27(3):273-283. [Abstract]
- BMC Oral Health. 2025 Sep 26;25(1):1472. [Abstract]
- Immunol Res. 2025 Jun 27;73(1):100. [Abstract]
- Front Biosci (Landmark Ed). 2024 Sep 24;29(9):334. [Abstract]
- Mol Immunol. 2025 May:181:102-112. [Abstract]
- Br J Nutr. 2024 Feb 28;131(4):553-566. [Abstract]
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- Toxicol Lett. 2025 Jul 21:412:34-43. [Abstract]
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- Mol Biol Rep. 2023 Aug;50(8):6457-6468. [Abstract]
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- Animals (Basel). 2023 Jul 13;13(14):2291. [Abstract]
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- Exp Ther Med. 2023 Sep 1;26(4):484. [Abstract]
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Customer Validation & Images
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WB
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Flow Cytometry
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
Biological Activity
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HDAC |
Sodium 4-phenylbutyrate (Sodium phenylbutyrate) is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. Sodium 4-phenylbutyrate in combination with ciglitizone results in enhanced growth arrest of cancer cells[1].
Sodium 4-phenylbutyrate (Sodium phenylbutyrate; 0-5 mM) inhibits ASFV infection in a dose-dependent manner. Sodium 4-phenylbutyrate also inhibits the ASFV late protein synthesis and disrupts the virus-induced H3K9/K14 hypoacetylation status. Sodium 4-phenylbutyrate and Enrofloxacin act synergistically to abolish ASFV replication[2].
Addition of Bafilomycin A1 results in accumulation of LC3II, whereas Benzenebutyric acid (4-PBA) substantially reduces this accumulation. LPS decreases the level of p62, whereas Benzenebutyric acid reverses this decrease upon LPS stimulation for 48 h. The percentage of cells with LPS-induced AVOs is increased at 48 h, whereas Benzenebutyric acid significantly reduces this percentage. Specifically, the percentage of cells with AVOs decreases from 61.6% to 53.1% upon Benzenebutyric acid treatment, supporting that Benzenebutyric acid inhibits LPS-induced autophagy. As a positive control for autophagy inhibition, bafilomycin A1 is used. The percentage of cells with LPS-induced AVOs is reduced by bafilomycin A1 treatment. The decreased OC area and fusion index observed after Benzenebutyric acid treatment are not observed with knockdown of ATG7. Inhibition of NF-κB using BAY 11-7082 and JSH23 reduce the LC3 II level upon LPS stimulation and completely abolish the inhibitory effect of Benzenebutyric acid on LPS-induced effects[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1716-12-7
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Appearance Solid
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Molecular Weight 186.18
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Formula C10H11NaO2
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Color White to off-white
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SMILES
O=C(O[Na])CCCC1=CC=CC=C1
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Synonyms
4-PBA sodium; 4-Phenylbutyric acid sodium; Benzenebutyric acid sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (240)
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Journal Impact Factor
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Most Recent
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Science
2026 Feb 26;391(6788):eads4405. PMID: 41747053 -
Cell
2025 Aug 7;188(16):4441-4455.e16. PMID: 40436017 -
Bioact Mater
Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles. [Abstract]2023 Apr 14:27:257-270. PMID: 37122894
Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Apr 14:27:257-270. [Abstract]
The protein levels of key molecules of ER stress and apoptosis in HG-induced fibroblasts after NET (1000 ng/mL, 24 h) treatment with or without pre-incubation for 1.5 h with 4-PBA (5 μM) or DNase I (2 U/mL).
Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Apr 14:27:257-270. [Abstract]
Edu assays were used to assess the proliferation of HG-induced fibroblasts after 24 hours of treatment with 4-PBA (5 μM) or DNase I (2 U/mL). Edu, red;DAPI, blue.
Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Apr 14:27:257-270. [Abstract]
Migration ability of HG-induced fibroblasts was analyzed by transwell migration assay following the indicated treatment with 4-PBA (5 μM) or DNase I (2 U/mL) for 24 h.
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Nat Cell Biol
Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells. [Abstract]2024 Nov;26(11):1892-1902. PMID: 39261719
Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Nov;26(11):1892-1902. [Abstract]
Percentages and numbers of CD45.1+CD8+ OT-I Teff cells in the spleens of mice treated with 4PBA (200 mg/kg, ip) or PBS (n = 8 mice per group).
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Sci Immunol
Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors. [Abstract]2023 Sep 29;8(87):eabq2424. PMID: 37738362 -
Nat Commun
NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization. [Abstract]2025 Aug 29;16(1):8074. PMID: 40883305
Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 29;16(1):8074. [Abstract]
Western blot of the protein expression of ATF4, CHOP and the osteogenic marker BMP2 in the aortas from the male mice subjected to VitD3-induced vascular calcification, with or without treatment of 4PBA (20 mg/kg/day, ip).
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Acta Pharm Sin B
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis. [Abstract]2024 Aug;14(8):3493-3512. PMID: 39220878 -
Acta Pharm Sin B
The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1 α/XBP1s pathway. [Abstract]2022 May;12(5):2315-2329. PMID: 35646520 -
Autophagy
Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway. [Abstract]2022 Oct;18(10):2350-2367. PMID: 35130104 -
Autophagy
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. [Abstract]2021 Nov;17(11):3592-3606. PMID: 33629929
Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Nov;17(11):3592-3606. [Abstract]
Cells are treated with 20 μM Cannabidiol for 24 h with or without pretreatment with 4-PBA (1 mM for 30 min); expression levels of ER stress and mitophagy related proteins are analyzed by western blotting.
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Adv Sci (Weinh)
Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis. [Abstract]2026 Apr;13(21):e14863. PMID: 41738282 -
Adv Sci (Weinh)
CHAC1 Mediates Endoplasmic Reticulum Stress-Dependent Ferroptosis in Calcium Oxalate Kidney Stone Formation. [Abstract]2025 Jan 21:e2403992. PMID: 39836526 -
Adv Sci (Weinh)
siRNA/CS-PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity. [Abstract]2024 Sep 19:e2403442. PMID: 39297413 -
J Adv Res
Hyperuricemia increases susceptibility to chronic kidney injury exacerbation via autophagic flux blockade-mediated ammonia death pathway. [Abstract]2025 Nov 7:S2090-1232(25)00877-X. PMID: 41205802 -
J Exp Clin Cancer Res
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer. [Abstract]2023 Jun 19;42(1):150. PMID: 37337284 -
Small
Silica Nanoparticles Trigger Chaperone HSPB8-Assisted Selective Autophagy via TFEB Activation in Hepatocytes. [Abstract]2023 Feb;19(5):e2204310. PMID: 36464658 -
J Hazard Mater
Tributyltin chloride (TBTCL) induces cell injury via dysregulation of endoplasmic reticulum stress and autophagy in Leydig cells. [Abstract]2023 Apr 15:448:130785. PMID: 36860030 -
Cell Mol Biol Lett
Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. [Abstract]2023 Oct 12;28(1):79. PMID: 37828427 -
Cancer Lett
YTHDF2-mediated stabilization of SREBF1 promotes lipid metabolic reprogramming and ferroptosis-associated radioresistance in anaplastic thyroid carcinoma. [Abstract]2025 Dec 21:639:218232. PMID: 41435981 -
Cancer Lett
Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy. [Abstract]2022 Feb 1:526:352-362. PMID: 34798195 -
Cancer Lett
Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells. [Abstract]2021 Jul 1:509:13-25. PMID: 33836250 -
Environ Int
Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats. [Abstract]2023 Oct:180:108228. PMID: 37802007 -
Environ Int
Triphenyl phosphate proved more potent than its metabolite diphenyl phosphate in inducing hepatic insulin resistance through endoplasmic reticulum stress. [Abstract]2023 Feb:172:107749. PMID: 36680801 -
Cell Death Dis
IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma. [Abstract]2025 Jul 11;16(1):512. PMID: 40645933 -
Cell Death Dis
NIR-715 photodynamic therapy induces immunogenic cancer cell death by enhancing the endoplasmic reticulum stress response. [Abstract]2024 Dec 18;15(12):890. PMID: 39695072 -
Cell Death Dis
The cytoplasmic-nuclear transport of DDX3X promotes immune-mediated liver injury in mice regulated by endoplasmic reticulum stress. [Abstract]2024 Sep 30;15(9):702. PMID: 39349420 -
Cell Death Dis
Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC. [Abstract]2022 Nov 10;13(11):951. PMID: 36357365 -
Cell Death Dis
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway. [Abstract]2021 Jun 11;12(6):606. PMID: 34117211 -
Cell Death Dis
CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade. [Abstract]2020 Apr 24;11(4):279. PMID: 32332705 -
Cell Death Dis
NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway. [Abstract]2018 Nov 16;9(12):1143. PMID: 30446635 -
Dev Cell
GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. [Abstract]2024 Jul 3:S1534-5807(24)00385-X. PMID: 38981469 -
Int J Biol Macromol
Genome-wide CRISPR screen identifies ALG5, ALG6, NF2, and FUT8 as key host proteins involved in transmissible gastroenteritis virus infection. [Abstract]2025 Dec;333(Pt 2):148770. PMID: 41205942 -
Int J Biol Macromol
Krüppel-like transcription factor 14 alleviates alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress in pulmonaryfibrosis. [Abstract]2024 Sep 11:135351. PMID: 39270890 -
Int J Biol Macromol
p20BAP31 promotes cell apoptosis via interaction with GRP78 and activating the PERK pathway in colorectal cancer. [Abstract]2024 Jun 4;272(Pt 2):132870. PMID: 38844291 -
Phytomedicine
Flemiphilippinin A induces paraptosis in lung cancer cells via c-Myc-driven endoplasmic reticulum stress and CHOP-mediated mitochondrial dysfunction. [Abstract]2025 Oct:146:157098. PMID: 40716126 -
Phytomedicine
Palmitic acid enhances the sensitivity of ferroptosis via endoplasmic reticulum stress mediated the ATF4/TXNIP Axis in polycystic ovary syndrome. [Abstract]2025 Jul:142:156777. PMID: 40393214 -
Free Radic Biol Med
Cepharanthine-induced mitophagy through regulation of FBXL4-BNIP3 drives ferroptosis leading to robust anti-lung cancer efficacy. [Abstract]2026 Jan:242:345-363. PMID: 41177235 -
Free Radic Biol Med
TRIB2 promotes pulmonary artery smooth muscle cell proliferation through SERCA2 ubiquitination in pulmonary hypertension. [Abstract]2025 Nov 8:243:414-433. PMID: 41213438 -
Free Radic Biol Med
Targeting ER stress/ROS-driven VEGF signaling axis: AdipoRon as a multifunctional therapeutic agent for alkali burn-induced corneal neovascularization. [Abstract]2025 Sep 10:S0891-5849(25)00969-4. PMID: 40939851 -
Free Radic Biol Med
CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH. [Abstract]2025 Aug 16:236:188-203. PMID: 40414463 -
Free Radic Biol Med
Autophagy and Endoplasmic Reticulum Stress-Related Protein Homeostasis Links Palmitic Acid to Hepatic Lipotoxicity in Zebrafish (Danio rerio), Counteracted by Linoleic Acid. [Abstract]2025 Jun:233:148-161. PMID: 40089081 -
Free Radic Biol Med
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. [Abstract]2023 Sep:206:33-49. PMID: 37364692 -
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Chemosphere
Black phosphorus quantum dots induce autophagy and apoptosis of human bronchial epithelial cells via endoplasmic reticulum stress. [Abstract]2023 Jun:327:138463. PMID: 36966929 -
Chemosphere
Fine particulate matter induces heart defects via AHR/ROS-mediated endoplasmic reticulum stress. [Abstract]2022 Nov;307(Pt 2):135962. PMID: 35948106 -
Sci Total Environ
Dissection of the potential mechanism of polystyrene microplastic exposure on cardiomyocytes. [Abstract]2025 Apr 10:973:179048. PMID: 40101404 -
Sci Total Environ
Perfluoroalkyl sulfonate induces cardiomyocyte apoptosis via endoplasmic reticulum stress activation and autophagy flux inhibition. [Abstract]2024 Jun 20:930:172582. PMID: 38649052 -
Sci Total Environ
Nano‑selenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP-NLRP3 pathway. [Abstract]2024 Mar 10:915:170129. PMID: 38242456 -
Sci Total Environ
Dibutyl phthalate causes heart damage by disrupting Ca2+ transfer from endoplasmic reticulum to mitochondria and triggering subsequent pyroptosis. [Abstract]2023 Sep 20:892:164620. PMID: 37270010 -
Environ Res
Endoplasmic reticulum stress mediates oxidative stress-driven endothelial impairment and atherogenesis induced by sodium perfluorononenoxybenzene sulfonate exposure. [Abstract]2026 Mar 24:299:124344. PMID: 41887487 -
Br J Pharmacol
Substitution of SERCA2 Cys674 accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis. [Abstract]2022 Sep;179(17):4423-4439. PMID: 35491240 -
J Transl Med
Mogroside V reduced the excessive endoplasmic reticulum stress and mitigated the Ulcerative colitis induced by dextran sulfate sodium in mice. [Abstract]2024 May 21;22(1):488. PMID: 38773576 -
Anim Nutr
Zearalenone induces apoptosis and autophagy by regulating endoplasmic reticulum stress signalling in porcine trophectoderm cells. [Abstract]2022 Oct 5:12:186-199. PMID: 36712409 -
Arterioscler Thromb Vasc Biol
Endothelial Intracellular ANG (Angiogenin) Protects Against Atherosclerosis by Decreasing Endoplasmic Reticulum Stress. [Abstract]2022 Mar;42(3):305-325. PMID: 35045729 -
Environ Pollut
ERα-mediated endoplasmic reticulum stress drives 4-tert-octylphenol-induced cardiac developmental toxicity in zebrafish. [Abstract]2026 Apr 15:395:127832. PMID: 41713771 -
Oncogene
m6A modification of lipoyltransferase 1 inhibits bladder cancer progression by activating cuproptosis. [Abstract]2024 Sep;43(40):2971-2985. PMID: 39198615 -
Environ Pollut
Perturbation of IP3R-dependent endoplasmic reticulum calcium homeostasis by PPARδ-activated metabolic stress leads to mouse spermatocyte apoptosis: A direct mechanism for perfluorooctane sulfonic acid-induced spermatogenic disorders. [Abstract]2024 Feb 15:343:123167. PMID: 38110051 -
Cell Death Discov
Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling. [Abstract]2024 Jun 8;10(1):275. PMID: 38851781 -
Cell Death Discov
IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway. [Abstract]2024 Feb 20;10(1):91. PMID: 38378646 -
Cell Death Discov
Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis. [Abstract]2023 Aug 14;9(1):296. PMID: 37580343 -
Cell Rep
Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth. [Abstract]2025 Mar 26;44(4):115470. PMID: 40146774 -
Int J Nanomedicine
Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer. [Abstract]2025 Jan 30:20:1147-1169. PMID: 39902066 -
Elife
2020 Dec 7;9:e61405. PMID: 33284104 -
Phytother Res
Curcumol Alleviates Ferroptosis in Metabolic-Associated Fatty Liver Disease by Inhibiting EGFR-Endoplasmic Reticulum Stress Axis. [Abstract]2026 Apr;40(4):1886-1902. PMID: 41629123 -
Comput Biol Med
Mechanistic study of ANXA3-mediated endoplasmic reticulum stress promoting M1 macrophage polarization in pulmonary arterial hypertension based on bioinformatics and nine machine learning algorithms. [Abstract]2025 Oct 18;198(Pt B):111215. PMID: 41110296 -
Phytother Res
A Small Molecular Weight Saccharide Fraction From Panax quinquefolium L. Inhibited Non-Small Cell Lung Cancer via Endoplasmic Reticulum-Stress Mediated Apoptosis. [Abstract]2025 Jul 15. PMID: 40662451 -
Phytother Res
Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells. [Abstract]2023 Jan;37(1):310-328. PMID: 36086867 -
Cell Biosci
FAK-dependent activation of src family kinase member BLK contributed to endometrial fibrosis via endoplasmic reticulum stress. [Abstract]2025 Oct 31;15(1):150. PMID: 41174819 -
J Agric Food Chem
Deoxynivalenol and Aflatoxin B1 Coexposure Aggravated Intestinal Damage via ER Stress-Meditated Mitochondrial Dyshomeostasis and Apoptosis. [Abstract]2025 Oct 29. PMID: 41160419 -
J Agric Food Chem
New Insights into Decabromodiphenyl Ether-Induced Splenic Injury in Chickens: Involvement of ROS-Mediated Endoplasmic Reticulum Stress Pathway Triggering Autophagy and Apoptosis. [Abstract]2024 Feb 21;72(7):3741-3754. PMID: 38340082 -
Ecotoxicol Environ Saf
The role of inositol-requiring enzyme 1α in gestational arsenic-induced α-KG collapse in male offspring. [Abstract]2025 Oct 15:305:119188. PMID: 41066812 -
Ecotoxicol Environ Saf
2024 Nov 1:286:117243. PMID: 39447294 -
Ecotoxicol Environ Saf
Endoplasmic reticulum stress promotes oxidative stress, inflammation, and apoptosis: A novel mechanism of citrinin-induced renal injury and dysfunction. [Abstract]2024 Aug 28:284:116946. PMID: 39208586 -
Ecotoxicol Environ Saf
ATF4-mediated different mode of interaction between autophagy and mTOR determines cell fate dependent on the level of ER stress induced by Cr(VI). [Abstract]2024 Jul 3:281:116639. PMID: 38964069 -
Antioxid Redox Signal
Mitofusin2 ameliorated ER stress and mitochondrial ROS through maintaining mitochondria-associated ER membrane integrity in cisplatin-induced acute kidney injury. [Abstract]2024 Jan;40(1-3):16-39. PMID: 37053105 -
Ecotoxicol Environ Saf
2023 Apr 15:255:114725. PMID: 36924558 -
Ecotoxicol Environ Saf
Exploring the molecular mechanisms underlie the endoplasmic reticulum stress-mediated methylmercury-induced neuronal developmental damage. [Abstract]2022 Oct 15:245:114099. PMID: 36152427 -
Ecotoxicol Environ Saf
Perfluorooctanoic acid exposure increases both proliferation and apoptosis of human placental trophoblast cells mediated by ER stress-induced ROS or UPR pathways. [Abstract]2022 May 1;236:113508. PMID: 35427876 -
Int J Mol Med
Hesperetin induces apoptosis in lung squamous carcinoma cells via G2/M cycle arrest, inhibition of the Notch1 pathway and activation of endoplasmic reticulum stress. [Abstract]2025 May;55(5):77. PMID: 40084686 -
J Invest Dermatol
Development of a Cellular Assay as a Personalized Model for Testing Chronic Wound Therapeutics. [Abstract]2025 Mar;145(3):631-644.e22. PMID: 38960086 -
Biochem Pharmacol
Maresin1 ameliorates osseointegration in type 2 diabetes mellitus by promoting FAM134B-mediated ER-phagy in osteoblasts. [Abstract]2025 Oct:240:117099. PMID: 40619017 -
Biochem Pharmacol
Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. [Abstract]2024 May:223:116194. PMID: 38583812 -
Biochem Pharmacol
Potent salinomycin C20-O-alkyl oxime derivative SAL-98 efficiently inhibits tumor growth and metastasis by affecting Wnt/β-catenin signal pathway. [Abstract]2023 Aug:214:115666. PMID: 37391086 -
Biochem Pharmacol
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress. [Abstract]2023 Feb:208:115404. PMID: 36592709 -
Biochem Pharmacol
Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis. [Abstract]2022 Dec:206:115343. PMID: 36370754 -
Virulence
The T-type voltage-gated Ca2+ channel CaV3.1 involves in the disruption of respiratory epithelial barrier induced by Pasteurella multocida toxin. [Abstract]2025 Dec;16(1):2466482. PMID: 39950866 -
Mar Drugs
Cholestane-3β,5α,6β-triol Induces Multiple Cell Death in A549 Cells via ER Stress and Autophagy Activation. [Abstract]2024 Apr 13;22(4):174. PMID: 38667791 -
J Ethnopharmacol
Screening of anti-melanoma compounds from Morus alba L.: Sanggenon C promotes melanoma cell apoptosis by disrupting intracellular Ca2+ homeostasis. [Abstract]2024 Apr 24:324:117759. PMID: 38219884 -
J Ethnopharmacol
Zanthoxylum armatum DC fruit ethyl acetate extract site induced hepatotoxicity by activating endoplasmic reticulum stress and inhibiting autophagy in BRL-3A models. [Abstract]2023 Oct 5;319(Pt 2):117245. PMID: 37802376 -
Chem Biol Interact
Depleted uranium induces thyroid damage through activation of ER stress via the thrombospondin 1-PERK pathway. [Abstract]2023 Sep 1:382:110592. PMID: 37270086 -
Chem Biol Interact
Hexavalent chromium disrupts the skin barrier by targeting ROS-mediated mitochondrial pathway apoptosis in keratinocytes. [Abstract]2023 Jul 1:379:110523. PMID: 37146930 -
J Ethnopharmacol
PI3K/AKT/mTOR, NF-κB and ERS pathway participated in the attenuation of H2O2-induced IPEC-J2 cell injury by koumine. [Abstract]2023 Mar 25:304:116028. PMID: 36529250 -
Chem Biol Interact
Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated paraptosis accompanied by autophagosome accumulation. [Abstract]2022 Oct 1:366:110125. PMID: 36027945 -
Cells
CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease. [Abstract]2022 Nov 26;11(23):3792. PMID: 36497052 -
Life Sci
Endoplasmic reticulum stress and autophagy as potential therapeutic targets in SERPINF1 mutation-induced type VI osteogenesis imperfecta. [Abstract]2025 Jul 19:379:123862. PMID: 40692043 -
Commun Biol
Small GTP-binding protein GDP dissociation stimulator influences cisplatin-induced acute kidney injury via PERK-dependent ER stress. [Abstract]2024 Sep 5;7(1):1091. PMID: 39237614 -
Foods
Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress. [Abstract]2023 Apr 11;12(8):1616. PMID: 37107412 -
Life Sci
Endoplasmic reticulum stress contributes to pyroptosis through NF-κB/NLRP3 pathway in diabetic nephropathy. [Abstract]2023 Jun 1:322:121656. PMID: 37011874 -
Respir Res
Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation. [Abstract]2025 Apr 12;26(1):136. PMID: 40221718 -
Respir Res
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis. [Abstract]2024 Nov 9;25(1):401. PMID: 39522031 -
Respir Res
HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo. [Abstract]2023 Jun 2;24(1):149. PMID: 37268944 -
Int J Mol Sci
Cartilage Intermediate Layer Protein 2 Aggravates Hepatic Lipid Accumulation and Inflammation Through the IRE1α/XBP1 Pathway. [Abstract]2026 Jan 25;27(3):1213. PMID: 41683641 -
Biol Direct
Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway. [Abstract]2025 Aug 22;20(1):94. PMID: 40847353 -
Int J Mol Sci
The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis. [Abstract]2023 Feb 1;24(3):2749. PMID: 36769070 -
Int J Mol Sci
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress. [Abstract]2023 Jan 5;24(2):1015. PMID: 36674530 -
Pharmaceuticals (Basel)
Mazdutide Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Endoplasmic Reticulum Stress, Improving Lipid Metabolism and Alleviating Inflammation. [Abstract]2026 Feb 26;19(3):371. PMID: 41901218 -
Ann N Y Acad Sci
Helicobacter mastomyrinus Cytolethal Distending Toxin Induces Calcium Dyshomeostasis and Liver Injury via Endoplasmic Reticulum Stress. [Abstract]2026 Feb;1556(1):e70159. PMID: 41681127 -
Cell Mol Neurobiol
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson's Disease. [Abstract]2025 May 29;45(1):53. PMID: 40439946 -
Biomolecules
Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca2+]i Stability between Endoplasmic Reticulum and Mitochondria. [Abstract]2024 Sep 8;14(9):1135. PMID: 39334901 -
Biomolecules
GRP75 Modulates Endoplasmic Reticulum-Mitochondria Coupling and Accelerates Ca2+-Dependent Endothelial Cell Apoptosis in Diabetic Retinopathy. [Abstract]2022 Nov 29;12(12):1778. PMID: 36551205 -
Front Cell Infect Microbiol
Inhibition of Porcine Epidemic Diarrhea Virus by Cinchonine via Inducing Cellular Autophagy. [Abstract]2022 Jun 14:12:856711. PMID: 35774410 -
Front Pharmacol
2022 Mar 21;13:854506. PMID: 35387352 -
Front Pharmacol
CHOP Regulates Endoplasmic Reticulum Stress-Mediated Hepatoxicity Induced by Monocrotaline. [Abstract]2021 May 24:12:685895. PMID: 34108882 -
Int Immunopharmacol
Total glucosides of paeony ameliorate post-stroke depression-like behaviors by modulating inflammasome activation via inhibition of endoplasmic reticulum stress. [Abstract]2026 Mar 15:173:116304. PMID: 41621387 -
Int Immunopharmacol
Targeting GCS regulates the NRF2 axis to inhibit hepatocyte endoplasmic reticulum stress-ferroptosis improving immune-mediated liver injury. [Abstract]2025 Sep 13:165:115532. PMID: 40946670 -
Int Immunopharmacol
Targeting PARK7: Sodium 4-Phenylbutyrate shields endothelial cells from oxidative stress and GSDME-mediated Pyroptosis in acute lung injury. [Abstract]2025 Aug 19:164:115386. PMID: 40834532 -
Int Immunopharmacol
Trichinella spiralis serine protease inhibitors regulate the dynamic interaction between endoplasmic reticulum stress and autophagy in host intestinal epithelial cells. [Abstract]2025 Jun 11:161:115005. PMID: 40505235 -
Am J Physiol Cell Physiol
2025 Mar 1;328(3):C1076-C1089. PMID: 39982446 -
Int Immunopharmacol
Maackiain induces apoptosis and autophagy via ROS-mediated endoplasmic reticulum stress in endometrial cancer. [Abstract]2025 Jan 4:147:113935. PMID: 39756166 -
Int Immunopharmacol
Resveratrol attenuates inflammation and apoptosis through alleviating endoplasmic reticulum stress via Akt/mTOR pathway in fungus-induced allergic airways inflammation. [Abstract]2022 Feb:103:108489. PMID: 34968999 -
Int Immunopharmacol
Ephedrine ameliorates chronic obstructive pulmonary disease (COPD) through restraining endoplasmic reticulum (ER) stress in vitro and in vivo. [Abstract]2022 Feb:103:107842. PMID: 34953449 -
Int Immunopharmacol
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome. [Abstract]2021 Dec;101(Pt A):108281. PMID: 34710848 -
Biosci Rep
Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy. [Abstract]2019 Aug 7;39(8):BSR20190578. PMID: 31285389 -
Toxicology
Particulate matter induced cognitive impairments via endoplasmic reticulum stress-mediated damage to mitochondria-associated endoplasmic reticulum membranes in immature rats. [Abstract]2024 Dec:509:153979. PMID: 39442789 -
Toxicology
ATF4/PHGDH mediates the effects of ER stress on cadmium-induced autophagy and glycolysis. [Abstract]2024 Dec:509:153976. PMID: 39427783 -
Toxicology
HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth and cell migration. [Abstract]2024 Jul 18:153899. PMID: 39032683 -
Toxicology
Differential susceptibility of BRL cells with/without insulin resistance and the role of endoplasmic reticulum stress signaling pathway in response to acrylamide-exposure toxicity effects in vitro. [Abstract]2024 May:504:153800. PMID: 38604440 -
Toxicology
Endoplasmic reticulum stress promotes blood-testis barrier impairment in mice with busulfan-induced oligospermia through PERK-eIF2α signaling pathway. [Abstract]2022 May 15;473:153193. PMID: 35533795 -
Cancers (Basel)
Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism. [Abstract]2025 Dec 27;18(1):92. PMID: 41514605 -
J Dairy Sci
AMPK-endoplasmic reticulum stress axis contributes to lipopolysaccharide-caused mitochondrial dysfunction by regulating mitochondria-associated membrane function in bovine hepatocytes. [Abstract]2023 Jul;106(7):5146-5164. PMID: 37225589 -
Mol Neurobiol
PDZD8 Dysregulation Mediates RVLM Neuronal Hyperexcitation Via Activation of Ca2+-Calpain-2 Signaling in Stress-Induced Hypertension. [Abstract]2025 May 26. PMID: 40418411 -
FASEB J
Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis. [Abstract]2026 Mar 31;40(6):e71636. PMID: 41842655 -
Mediators Inflamm
After Traumatic Brain Injury, EPHA4 Enhances Endoplasmic Reticulum Stress to Promote M1 Microglial Polarization Through the MAPK Signaling Pathway. [Abstract]2026 Jan 22:2026:5595023. PMID: 41583121 -
FASEB J
Elesclomol-Induced Copper Influx Attenuates Lung Adenocarcinoma Progression With Involvement of the ER Stress/PCK2 Axis. [Abstract]2025 Nov 30;39(22):e71250. PMID: 41251612 -
Lipids Health Dis
Chronic hypoxia induces liver injury via PKCδ/ASMase-driven ceramide accumulation and endoplasmic reticulum stress in rats. [Abstract]2025 Oct 7;24(1):312. PMID: 41057877 -
Lipids Health Dis
2025 Apr 12;24(1):138. PMID: 40221727 -
FASEB J
2025 Mar 31;39(6):e70345. PMID: 40079196 -
Lipids Health Dis
Arachidonic acid is involved in high-salt diet-induced coronary remodeling through stimulation of the IRE1α/XBP1s/RUNX2/OPN signaling cascade. [Abstract]2025 Feb 11;24(1):44. PMID: 39934848 -
Poult Sci
Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens. [Abstract]2024 Jun;103(6):103656. PMID: 38583308 -
Exp Neurol
4-PBA exerts brain-protective effects against sepsis-associated encephalopathy in a mouse model of sepsis. [Abstract]2024 May:375:114738. PMID: 38395217 -
Lab Invest
Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice. [Abstract]2022 Nov;102(11):1192-1202. PMID: 35941186 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
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J Lipid Res
Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells. [Abstract]2024 Nov 4:100692. PMID: 39505261 -
Nutr Metab
Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis. [Abstract]2020 Jan 30;17:11. PMID: 32021639 -
Toxins
Deoxynivalenol-Induced Spleen Toxicity in Mice: Inflammation, Endoplasmic Reticulum Stress, Macrophage Polarization, and the Dysregulation of LncRNA Expression. [Abstract]2024 Oct 9;16(10):432. PMID: 39453208 -
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Biomedicines
2025 Aug 6;13(8):1919. PMID: 40868174 -
Sci Rep
USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells. [Abstract]2025 May 5;15(1):15659. PMID: 40325079 -
Fish Shellfish Immunol
Grass Carp Reovirus (GCRV) infection activates the PERK-eIF2α pathway to promote the viral replication. [Abstract]2024 Nov 9:155:110020. PMID: 39528019 -
Biomedicines
N-Acetylcysteine Attenuates Sepsis-Induced Muscle Atrophy by Downregulating Endoplasmic Reticulum Stress. [Abstract]2024 Apr 18;12(4):902. PMID: 38672256 -
Sci Rep
Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress. [Abstract]2023 Nov 9;13(1):19438. PMID: 37945738 -
Sci Rep
Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer. [Abstract]2023 Jan 13;13(1):693. PMID: 36639421 -
Sci Rep
Sulforaphane ameliorates bisphenol A-induced hepatic lipid accumulation by inhibiting endoplasmic reticulum stress. [Abstract]2023 Jan 20;13(1):1147. PMID: 36670177 -
Virol J
Endoplasmic reticulum stress inhibitor 4-PBA alleviates immune damage in mice with enteroviral encephalitis by inhibiting ferroptosis. [Abstract]2026 Mar 21;23(1):114. PMID: 41862947 -
Neurochem Res
4-Phenylbutyrate Induces Functional Elongation of the Microglial Process Through Activation of Akt. [Abstract]2026 Feb 7;51(1):66. PMID: 41653373 -
Cell Signal
Rosuvastatin inhibits carcinogenesis through Ca2+ triggered endoplasmic reticulum stress pathway in pancreatic cancer. [Abstract]2025 Jul:131:111753. PMID: 40107481 -
Vet Res
Glaesserella parasuis infection triggers endoplasmic reticulum stress-mediated pyroptosis via PERK/eIF2α/ATF4 axis and metabolic reprogramming in porcine alveolar macrophages. [Abstract]2025 Jul 15;56(1):150. PMID: 40665414 -
Vet Res
Regulatory effects of Trichinella spiralis serpin-type serine protease inhibitor on endoplasmic reticulum stress and oxidative stress in host intestinal epithelial cells. [Abstract]2024 Jun 14;55(1):78. PMID: 38877574 -
Mol Med Rep
Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress. [Abstract]2024 May;29(5):71. PMID: 38456480 -
J Neuroimmune Pharmacol
Alleviating CB2-Dependent ER Stress and Mitochondrial Dysfunction Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment. [Abstract]2024 Jan 12;19(1):1. PMID: 38214766 -
Food Chem Toxicol
Deoxynivalenol induces endoplasmic reticulum stress-associated apoptosis via the IRE1/JNK/CHOP pathway in porcine alveolar macrophage 3D4/21 cells. [Abstract]2023 Oct:180:114033. PMID: 37739053 -
Vet Res
The novel Nsp9-interacting host factor H2BE promotes PEDV replication by inhibiting endoplasmic reticulum stress-mediated apoptosis. [Abstract]2023 Mar 22;54(1):27. PMID: 36949543 -
Viruses
4-Phenyl-butyric Acid Inhibits Japanese Encephalitis Virus Replication via Inhibiting Endoplasmic Reticulum Stress Response. [Abstract]2023 Feb 14;15(2):534. PMID: 36851748 -
Food Chem Toxicol
Fumonisin B1 induced intestinal epithelial barrier damage through endoplasmic reticulum stress triggered by the ceramide synthase 2 depletion. [Abstract]2022 Aug:166:113263. PMID: 35777715 -
Food Chem Toxicol
Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress. [Abstract]2020 Jun;140:111329. PMID: 32283200 -
Food Chem Toxicol
Involvement of PERK-CHOP pathway in fumonisin B1- induced cytotoxicity in human gastric epithelial cells. [Abstract]2020 Feb;136:111080. PMID: 31891755 -
BMC Complement Med Ther
Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway. [Abstract]2024 Nov 16;24(1):400. PMID: 39550552 -
BMC Complement Med Ther
Rauwolfia vomitoria extract suppresses benign prostatic hyperplasia by inducing autophagic apoptosis through endoplasmic reticulum stress. [Abstract]2022 May 5;22(1):125. PMID: 35513857 -
Biochim Biophys Acta Mol Cell Biol Lipids
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE-/- mice via MBOAT2-mediated endoplasmic reticulum stress. [Abstract]2024 Aug 21:159559. PMID: 39179098 -
Chem Biol Drug Des
Curcumin affects apoptosis of colorectal cancer cells through ATF6-mediated endoplasmic reticulum stress. [Abstract]2024 Jan;103(1):e14433. PMID: 38230779 -
Front Oncol
Knockdown of Oligosaccharyltransferase Subunit Ribophorin 1 Induces Endoplasmic-Reticulum-Stress-Dependent Cell Apoptosis in Breast Cancer. [Abstract]2021 Oct 27;11:722624. PMID: 34778038 -
Front Oncol
Lamprey Immune Protein Mediates Apoptosis of Lung Cancer Cells Via the Endoplasmic Reticulum Stress Signaling Pathway. [Abstract]2021 Jul 7;11:663600. PMID: 34307136 -
Pathol Res Pract
Multi-omic and functional analyses identified an endoplasmic reticulum stress-driven TIMD4⁺ IL1β⁺ macrophage subpopulation contributes to osteoarthritis progression. [Abstract]2026 Jun:282:156442. PMID: 41875622 -
Pathol Res Pract
SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response. [Abstract]2026 May:281:156400. PMID: 41775211 -
Mol Carcinog
ZBTB7A interferes with the RPL5-P53 feedback loop and reduces endoplasmic reticulum stress-induced apoptosis of pancreatic cancer cells. [Abstract]2024 Sep;63(9):1783-1799. PMID: 38896079 -
Int J Med Sci
N-cadherin Alleviates Apoptosis and Senescence of Nucleus Pulposus Cells via Suppressing ROS-dependent ERS in the Hyper-osmolarity Microenvironment. [Abstract]2024 Jan 1;21(2):341-356. PMID: 38169592 -
Environ Toxicol
Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. [Abstract]2023 Aug;38(8):1874-1890. PMID: 37148176 -
Cell Stress Chaperones
Replication of standard bovine viral diarrhea strain OregonC24Va induces endoplasmic reticulum stress-mediated apoptosis of bovine trophoblast cells. [Abstract]2023 Jan;28(1):49-60. PMID: 36441379 -
Cell Stress Chaperones
Role of endoplasmic reticulum stress in apoptosis induced by HK2 inhibitor and its potential as a new drug combination strategy. [Abstract]2022 May;27(3):273-283. PMID: 35355227 -
BMC Oral Health
PMAIP1 mediates endoplasmic reticulum stress in human dental pulp stem cells during pulpitis pathogenesis. [Abstract]2025 Sep 26;25(1):1472. PMID: 41013511 -
Immunol Res
HBV infection upregulates GP73 expression to promote liver fibrosis by enhancing ER stress via the Smad2 pathway. [Abstract]2025 Jun 27;73(1):100. PMID: 40571844 -
Front Biosci (Landmark Ed)
ACE2 Alleviates Endoplasmic Reticulum Stress and Protects against Pyroptosis by Regulating Ang1-7/Mas in Ventilator-Induced Lung Injury. [Abstract]2024 Sep 24;29(9):334. PMID: 39344337 -
Mol Immunol
IL-33 facilitates endoplasmic reticulum stress and pyroptosis in LPS-stimulated ARDS model in vitro. [Abstract]2025 May:181:102-112. PMID: 40118005 -
Br J Nutr
Dietary palm oil enhances SREBP2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker ( Larimichthys crocea). [Abstract]2024 Feb 28;131(4):553-566. PMID: 37699661 -
Mol Immunol
Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages. [Abstract]2021 Jul:135:294-303. PMID: 33957479 -
Toxicol Lett
2025 Jul 21:412:34-43. PMID: 40701419 -
Mol Biol Rep
Specnuezhenide mitigates tunicamycin-induced liver injury in mice via ER stress modulation and metabolic reprogramming. [Abstract]2025 Aug 11;52(1):814. PMID: 40788369 -
Endocr Connect
Endoplasmic reticulum stress contributes to insulin resistance in Hashimoto's thyroiditis. [Abstract]2025 Aug 11;14(8):e250158. PMID: 40742333 -
J Biochem Mol Toxicol
Sesamol Alleviated Lipotoxicity-Induced Dysfunction in MIN6 Cells via Facilitating Cellular Senescence Caused by Endoplasmic Reticulum Stress. [Abstract]2024 Nov;38(11):e70038. PMID: 39470143 -
Mol Biol Rep
Mechanisms of autophagy and endoplasmic reticulum stress in the reversal of platinum resistance of epithelial ovarian cancer cells by naringin. [Abstract]2023 Aug;50(8):6457-6468. PMID: 37326754 -
J Orthop Surg Res
Daphnoretin relieves IL-1β-mediated chondrocytes apoptosis via repressing endoplasmic reticulum stress and NLRP3 inflammasome. [Abstract]2022 Nov 16;17(1):487. PMID: 36384642 -
Vet Microbiol
The PERK-eIF2α branch activates the NLRP3 inflammasome through the NF-κB signaling pathway to suppress NDV replication. [Abstract]2026 May:316:110968. PMID: 41793984 -
Vet Microbiol
Distinct mechanisms of ER stress-mediated autophagy induction by high- and low-virulence pseudorabies virus strains. [Abstract]2026 Mar:314:110914. PMID: 41621166 -
Exp Eye Res
2025 Dec 22:264:110820. PMID: 41435751 -
Vet Microbiol
PERK-mediated eIF2α phosphorylation suppresses porcine epidemic diarrhea virus replication by attenuating global protein synthesis and inducing IFN-Ⅰ production. [Abstract]2025 Jun 3:307:110559. PMID: 40494050 -
Vet Microbiol
Bovine parainfluenza virus type 3 infections induce ER stress-mediated autophagy to facilitate virus replication. [Abstract]2024 May:292:110051. PMID: 38513524 -
Animals (Basel)
BDE-47 Induces Mitochondrial Dysfunction and Endoplasmic Reticulum Stress to Inhibit Early Porcine Embryonic Development. [Abstract]2023 Jul 13;13(14):2291. PMID: 37508068 -
Vet Microbiol
GRAMD4 regulates PEDV-induced cell apoptosis inhibiting virus replication via the endoplasmic reticulum stress pathway. [Abstract]2023 Apr:279:109666. PMID: 36738512 -
Vet Microbiol
Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways. [Abstract]2021 Feb:253:108959. PMID: 33360915 -
BMC Vet Res
Pseudorabies virus infection induces lymphocyte depletion associated with cellular apoptosis and endoplasmic reticulum stress in the mouse spleen. [Abstract]2025 Nov 17;21(1):673. PMID: 41250160 -
Fish Physiol Biochem
Endoplasmic reticulum stress is involved in lipid accumulation induced by oleic acid in adipocytes of grass carp (Ctenopharyngodon idella): focusing on the transcriptional level. [Abstract]2022 Feb;48(1):275-284. PMID: 35091868 -
Toxicon
Endoplasmic reticulum stress promotes oxidative stress: A novel mechanism of citrinin-induced thymus and spleen injury. [Abstract]2025 Aug 7:266:108511. PMID: 40782931 -
PeerJ
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway. [Abstract]2022 May 12;10:e13376. PMID: 35582617 -
FEBS Open Bio
Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78-ATF6-CHOP signaling pathway. [Abstract]2025 Mar 28. PMID: 40152446 -
Behav Brain Res
Acupuncture Activates IRE1/XBP1 Endoplasmic Reticulum Stress Pathway in Parkinson's Disease Model Rats. [Abstract]2024 Mar 28:462:114871. PMID: 38266778 -
Exp Ther Med
Cucurbitacin B induces apoptosis in colorectal cells through reactive oxygen species generation and endoplasmic reticulum stress pathways. [Abstract]2023 Sep 1;26(4):484. PMID: 37753296 -
FEBS Open Bio
T-type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation. [Abstract]2020 Oct;10(10):2122-2136. PMID: 32865339 -
Biochem Biophys Rep
2025 Sep 15:44:102262. PMID: 41019290 -
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Biochem Biophys Rep
Sorafenib induces ferroptosis in human renal cell carcinoma cells through CCAT/enhancer-binding protein homologous protein. [Abstract]2025 Jul 7:43:102143. PMID: 40688501 -
Biochem Biophys Res Commun
Neutrophils suppress osteogenic differentiation of Gli1+ stem cells via neutrophil extracellular traps and contribute to bone loss in periodontitis. [Abstract]2024 Oct 28:737:150916. PMID: 39489114 -
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Toxicol Res (Camb)
The relationship between endoplasmic reticulum stress and autophagy in apoptosis of BEAS-2B cells induced by cigarette smoke condensate. [Abstract]2021 Jan 5;10(1):18-28. PMID: 33613969 -
J Burn Care Res
Role and mechanism of endoplasmic reticulum stress in mice pancreatic islet dysfunction after severe burns. [Abstract]2023 Sep 7;44(5):1231-1240. PMID: 36869805 -
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Neurol Res
AATF alleviates cerebral ischemia-reperfusion injury by suppressing endoplasmic reticulum stress-induced ferroptosis through upregulating the PI3K/Akt pathway. [Abstract]2025 Nov 10:1-17. PMID: 41215590 -
Bull Exp Biol Med
Fangchinoline Exerts Anticancer Effects on Colorectal Cancer Cells by Evoking Cell Apoptosis via Endoplasmic Reticulum Stress. [Abstract]2023 Mar;174(5):639-646. PMID: 37052856 -
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Oxid Med Cell Longev
ROS-Responsive miR-150-5p Downregulation Contributes to Cigarette Smoke-Induced COPD via Targeting IRE1 α. [Abstract]2022 May 5;2022:5695005. PMID: 35571237 -
Oxid Med Cell Longev
USP7 Attenuates Endoplasmic Reticulum Stress and NF- κ B Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation. [Abstract]2022 Apr 6;2022:1835900. PMID: 35432716 -
Oxid Med Cell Longev
Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLC β 1-Ca2+-Mediated Endoplasmic Reticulum Stress. [Abstract]2021 Jun 16:2021:5552530. PMID: 34221234
Solvent & Solubility
H2O : 100 mg/mL (537.11 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (537.11 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
Briefly, viable cells, as judged by trypan blue dye exclusion, are seeded at a density of 4 × 104 cells/mL in 60-mm dishes in RPMI 1640 with 10% fetal bovine serum and 0.35% agarose on a base layer of 0.7% agarose. DMSO, TSA, or PB is added to both bottom and top agarose layers. Assays are performed in triplicate on at least three separate occasions, and colonies are counted at 10-14 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mice[3]
Female 10-week-old C57BL/6J mice are housed in the pathogen-free animal facility of IRC. Animals are randomized into the following 4 groups: vehicle control (n=5), vehicle+Benzenebutyric acid (n=6), LPS (n=6), and LPS+Benzenebutyric acid (n=6). Mice are treated with LPS in 200 μL phosphate-buffered saline (PBS) once a week (5 mg/kg, i.p.) for 3 weeks. Sodium 4-phenylbutyrate (Benzenebutyric acid) solution is prepared by titrating equimolecular amounts of Benzenebutyric acid and sodium hydroxide to reach pH 7.4; mice are injected daily intraperitoneally in 200 μL PBS (or with PBS as a vehicle) at a dose of 240 mg/kg for 3 weeks. Mice are sacrificed by CO2 asphyxiation. To determine the bone mineral density (BMD) and microarchitecture of the long bone, the right femur is scanned. Scans are performed with an effective detector pixel size of 6.9 μm and a threshold of 77-255 mg/cc. Trabecular bone is analyzed in a region 1.6 mm in length and located 0.1 mm below the distal femur growth plate[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [Content Brief]
[2]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. [Content Brief]
[3]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.3711 mL | 26.8557 mL | 53.7115 mL | 134.2787 mL |
| 5 mM | 1.0742 mL | 5.3711 mL | 10.7423 mL | 26.8557 mL | |
| 10 mM | 0.5371 mL | 2.6856 mL | 5.3711 mL | 13.4279 mL | |
| 15 mM | 0.3581 mL | 1.7904 mL | 3.5808 mL | 8.9519 mL | |
| 20 mM | 0.2686 mL | 1.3428 mL | 2.6856 mL | 6.7139 mL | |
| 25 mM | 0.2148 mL | 1.0742 mL | 2.1485 mL | 5.3711 mL | |
| 30 mM | 0.1790 mL | 0.8952 mL | 1.7904 mL | 4.4760 mL | |
| 40 mM | 0.1343 mL | 0.6714 mL | 1.3428 mL | 3.3570 mL | |
| 50 mM | 0.1074 mL | 0.5371 mL | 1.0742 mL | 2.6856 mL | |
| 60 mM | 0.0895 mL | 0.4476 mL | 0.8952 mL | 2.2380 mL | |
| 80 mM | 0.0671 mL | 0.3357 mL | 0.6714 mL | 1.6785 mL | |
| 100 mM | 0.0537 mL | 0.2686 mL | 0.5371 mL | 1.3428 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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