DMF-DMA
Based on 1 Customer Validation
DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 4637-24-5
- Formula: C5H13NO2
- Molecular Weight:119.16
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DMF-DMA (Refluxed (unspecified duration)) reacts with thiazolidine compounds (19) under reflux in m-xylene to form enamine derivatives (20)[1].
DMF-DMA (10 h) reacts with annulene derivative (21) under reflux for 10 h to form E and Z enaminone compounds (22, 23) with 95% yield[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4637-24-5
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Appearance Liquid (Density: 0.899 g/cm3)
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Molecular Weight 119.16
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Formula C5H13NO2
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Color Colorless to light yellow
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SMILES
CN(C)C(OC)OC
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Synonyms
N-Dimethoxymethyl-N,N-dimethylamine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (839.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (930 KB)
- English - EN (930 KB)
- Français - FR (930 KB)
- Deutsch - DE (930 KB)
- Norwegian - NO (930 KB)
- Español - ES (930 KB)
- Swedish - SV (930 KB)
- Italian - IT (930 KB)
- Korean - KR (930 KB)
- Portuguese - PT (930 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.3921 mL | 41.9604 mL | 83.9208 mL | 209.8019 mL |
| 5 mM | 1.6784 mL | 8.3921 mL | 16.7842 mL | 41.9604 mL | |
| 10 mM | 0.8392 mL | 4.1960 mL | 8.3921 mL | 20.9802 mL | |
| 15 mM | 0.5595 mL | 2.7974 mL | 5.5947 mL | 13.9868 mL | |
| 20 mM | 0.4196 mL | 2.0980 mL | 4.1960 mL | 10.4901 mL | |
| 25 mM | 0.3357 mL | 1.6784 mL | 3.3568 mL | 8.3921 mL | |
| 30 mM | 0.2797 mL | 1.3987 mL | 2.7974 mL | 6.9934 mL | |
| 40 mM | 0.2098 mL | 1.0490 mL | 2.0980 mL | 5.2450 mL | |
| 50 mM | 0.1678 mL | 0.8392 mL | 1.6784 mL | 4.1960 mL | |
| 60 mM | 0.1399 mL | 0.6993 mL | 1.3987 mL | 3.4967 mL | |
| 80 mM | 0.1049 mL | 0.5245 mL | 1.0490 mL | 2.6225 mL | |
| 100 mM | 0.0839 mL | 0.4196 mL | 0.8392 mL | 2.0980 mL |
DMF-DMA Related Classifications
HY-Y1078 Related Classifications
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