LMO2 - LIM domain only 2 Gene
Also Known as TTG2; LMO-2; RBTN2; RHOM2; RBTNL1
Species: Homo sapiens
About LMO2
This gene has 6 transcripts (splice variants), 193 orthologues, 20 paralogues and is associated with 51 phenotypes. Broad expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.4) and 24 other tissues.
Summary
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
LMO2 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001142315.2 | NP_001135787.1 | rhombotin-2 isoform 2 |
| NM_001142316.2 | NP_001135788.1 | rhombotin-2 isoform 2 |
| NM_005574.4 | NP_005565.2 | rhombotin-2 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RNA polymerase II-specific DNA-binding transcription factor binding |
IPI
IPI: Inferred from physical interaction
|
16314316 | GOA |
| enables bHLH transcription factor binding |
IPI
IPI: Inferred from physical interaction
|
16314316 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| enables transcription coactivator activity |
IDA
IDA: Inferred from direct assay
|
16314316 | GOA |
| enables transcription coregulator binding |
IPI
IPI: Inferred from physical interaction
|
16314316 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
16314316 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of transcription regulator complex |
IDA
IDA: Inferred from direct assay
|
16314316 | GOA |
LMO2 Protein Structure
LIM: LIM domain (30 - 88)
LIM: LIM domain (94 - 150)
- 0
- 100
- 158 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
rhombotin-2 |
|
LMO2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
LMO2 | P25791 | MAPRE1 | Homo sapiens | Q15691 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MAPRE1 | Homo sapiens | Q15691 | 25416956 | |
|
Intra
|
LMO2 | P25791 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
LMO2 | P25791 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
LMO2 | P25791 | KRTAP10-7 | Homo sapiens | P60409 | 25416956 | |
|
Intra
|
LMO2 | P25791 | KRTAP10-7 | Homo sapiens | P60409 | 25416956 | |
|
Intra
|
LMO2 | P25791 | KRTAP10-7 | Homo sapiens | P60409 | 25416956 | |
|
Intra
|
LMO2 | P25791 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 25416956 | |
|
Intra
|
LMO2 | P25791 | TFPT | Homo sapiens | P0C1Z6-2 | 25416956 | |
|
Intra
|
LMO2 | P25791 | NUTM1 | Homo sapiens | Q86Y26 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MBIP | Homo sapiens | Q9NS73-5 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MAGEA8 | Homo sapiens | P43361 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MAGEA8 | Homo sapiens | P43361 | 25416956 | |
|
Intra
|
LMO2 | P25791 | IFT43 | Homo sapiens | Q96FT9 | 25416956 | |
|
Intra
|
LMO2 | P25791 | CLHC1 | Homo sapiens | Q8NHS4 | 25416956 | |
|
Intra
|
LMO2 | P25791 | CLHC1 | Homo sapiens | Q8NHS4 | 25416956 | |
|
Intra
|
LMO2 | P25791 | TRIM54 | Homo sapiens | Q9BYV2 | 25416956 | |
|
Intra
|
LMO2 | P25791 | SSX2IP | Homo sapiens | Q9Y2D8 | 25416956 | |
|
Intra
|
LMO2 | P25791 | SSX2IP | Homo sapiens | Q9Y2D8 | 25416956 | |
|
Intra
|
LMO2 | P25791 | N4BP2L2 | Homo sapiens | Q92802 | 25416956 | |
|
Intra
|
LMO2 | P25791 | N4BP2L2 | Homo sapiens | Q92802 | 25416956 | |
|
Intra
|
LMO2 | P25791 | N4BP2L2 | Homo sapiens | Q92802 | 25416956 | |
|
Intra
|
LMO2 | P25791 | BLZF1 | Homo sapiens | Q9H2G9 | 25416956 | |
|
Intra
|
LMO2 | P25791 | BLZF1 | Homo sapiens | Q9H2G9 | 25416956 | |
|
Intra
|
LMO2 | P25791 | CMTM5 | Homo sapiens | Q96DZ9 | 25416956 | |
|
Intra
|
LMO2 | P25791 | TUFT1 | Homo sapiens | Q9NNX1 | 25416956 | |
|
Intra
|
LMO2 | P25791 | TUFT1 | Homo sapiens | Q9NNX1 | 25416956 | |
|
Intra
|
LMO2 | P25791 | TUFT1 | Homo sapiens | Q9NNX1 | 25416956 | |
|
Intra
|
LMO2 | P25791 | REL | Homo sapiens | Q04864 | 25416956 | |
|
Intra
|
LMO2 | P25791 | SKP1 | Homo sapiens | P63208 | 25416956 | |
|
Intra
|
LMO2 | P25791 | SKP1 | Homo sapiens | P63208 | 25416956 | |
|
Intra
|
LMO2 | P25791 | SKP1 | Homo sapiens | P63208 | 25416956 | |
|
Intra
|
LMO2 | P25791 | SOX5 | Homo sapiens | P35711 | 25416956 | |
|
Intra
|
LMO2 | P25791 | SOX5 | Homo sapiens | P35711 | 25416956 | |
|
Intra
|
LMO2 | P25791 | HNRNPC | Homo sapiens | P07910 | 25416956 | |
|
Intra
|
LMO2 | P25791 | HNRNPC | Homo sapiens | P07910 | 25416956 | |
|
Intra
|
LMO2 | P25791 | PRKG1 | Homo sapiens | Q13976 | 31515488 | |
|
Intra
|
LMO2 | P25791 | PRKG1 | Homo sapiens | Q13976 | 25416956 | |
|
Intra
|
LMO2 | P25791 | PRKG1 | Homo sapiens | Q13976 | 25416956 | |
|
Intra
|
LMO2 | P25791 | SAXO1 | Homo sapiens | Q8IYX7 | 31515488 | |
|
Intra
|
LMO2 | P25791 | SAXO1 | Homo sapiens | Q8IYX7 | 25416956 | |
|
Intra
|
LMO2 | P25791 | GRB2 | Homo sapiens | P62993 | 25416956 | |
|
Intra
|
LMO2 | P25791 | GRB2 | Homo sapiens | P62993 | 25416956 | |
|
Intra
|
LMO2 | P25791 | STAT3 | Homo sapiens | P40763 | 25416956 | |
|
Intra
|
LMO2 | P25791 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
LMO2 | P25791 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
LMO2 | P25791 | LDB1 | Homo sapiens | Q86U70 | 33961781 | |
|
Intra
|
LMO2 | P25791 | LDB1 | Homo sapiens | Q86U70 | 25416956 | |
|
Intra
|
LMO2 | P25791 | LDB1 | Homo sapiens | Q86U70 | 21988832 | |
|
Intra
|
LMO2 | P25791 | ZNF24 | Homo sapiens | P17028 | 31515488 | |
|
Intra
|
LMO2 | P25791 | ZNF24 | Homo sapiens | P17028 | 25416956 | |
|
Intra
|
LMO2 | P25791 | ZFP64 | Homo sapiens | Q9NTW7 | 25416956 | |
|
Intra
|
LMO2 | P25791 | ZFP64 | Homo sapiens | Q9NTW7 | 25416956 | |
|
Intra
|
LMO2 | P25791 | DRAP1 | Homo sapiens | Q14919 | 25416956 | |
|
Intra
|
LMO2 | P25791 | PHC2 | Homo sapiens | Q8IXK0 | 25416956 | |
|
Intra
|
LMO2 | P25791 | PHC2 | Homo sapiens | Q8IXK0 | 21516116 | |
|
Intra
|
LMO2 | P25791 | TLE5 | Homo sapiens | Q08117 | 25416956 | |
|
Intra
|
LMO2 | P25791 | TLE5 | Homo sapiens | Q08117 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MAPRE3 | Homo sapiens | Q9UPY8 | 21516116 | |
|
Intra
|
LMO2 | P25791 | MAPRE3 | Homo sapiens | Q9UPY8 | 16189514 | |
|
Intra
|
LMO2 | P25791 | MAPRE3 | Homo sapiens | Q9UPY8 | 25416956 | |
|
Intra
|
LMO2 | P25791 | RINT1 | Homo sapiens | Q6NUQ1 | 25416956 | |
|
Intra
|
LMO2 | P25791 | RINT1 | Homo sapiens | Q6NUQ1 | 25416956 | |
|
Intra
|
LMO2 | P25791 | RINT1 | Homo sapiens | Q6NUQ1 | 31515488 | |
|
Intra
|
LMO2 | P25791 | RELA | Homo sapiens | Q04206 | 21988832 | |
|
Intra
|
LMO2 | P25791 | RELA | Homo sapiens | Q04206 | 21988832 | |
|
Intra
|
LMO2 | P25791 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
LMO2 | P25791 | CALCOCO2 | Homo sapiens | Q13137 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MAPRE2 | Homo sapiens | Q15555 | 16189514 | |
|
Intra
|
LMO2 | P25791 | MAPRE2 | Homo sapiens | Q15555 | 31515488 | |
|
Intra
|
LMO2 | P25791 | MAPRE2 | Homo sapiens | Q15555 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MAPRE2 | Homo sapiens | Q15555 | 33961781 | |
|
Intra
|
LMO2 | P25791 | MAPRE2 | Homo sapiens | Q15555 | 25416956 | |
|
Intra
|
LMO2 | P25791 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
LMO2 | P25791 | NIF3L1 | Homo sapiens | Q9GZT8 | 25416956 | |
|
Intra
|
LMO2 | P25791 | LZTS2 | Homo sapiens | Q9BRK4 | 25416956 | |
|
Intra
|
LMO2 | P25791 | LZTS2 | Homo sapiens | Q9BRK4 | 25416956 | |
|
Intra
|
LMO2 | P25791 | FHL3 | Homo sapiens | Q13643 | 25416956 | |
|
Intra
|
LMO2 | P25791 | FHL3 | Homo sapiens | Q13643 | 25416956 | |
|
Intra
|
LMO2 | P25791 | AGTRAP | Homo sapiens | Q6RW13 | 25416956 | |
|
Intra
|
LMO2 | P25791 | CBY2 | Homo sapiens | Q8NA61 | 25416956 | |
|
Intra
|
LMO2 | P25791 | CBY2 | Homo sapiens | Q8NA61 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
LMO2 | P25791 | ABI2 | Homo sapiens | Q9NYB9 | 29892012 | |
|
Intra
|
LMO2 | P25791 | ABI2 | Homo sapiens | Q9NYB9 | 25416956 | |
|
Intra
|
LMO2 | P25791 | GFAP | Homo sapiens | P14136 | 25416956 | |
|
Intra
|
LMO2 | P25791 | GFAP | Homo sapiens | P14136 | 25416956 | |
|
Intra
|
LMO2 | P25791 | BANP | Homo sapiens | Q8N9N5 | 25416956 | |
|
Intra
|
LMO2 | P25791 | AIMP2 | Homo sapiens | Q13155 | 25416956 | |
|
Intra
|
LMO2 | P25791 | AIMP2 | Homo sapiens | Q13155 | 25416956 | |
|
Intra
|
LMO2 | P25791 | AIMP2 | Homo sapiens | Q13155 | 25416956 | |
|
Intra
|
LMO2 | P25791 | HOOK1 | Homo sapiens | Q9UJC3 | 25416956 | |
|
Intra
|
LMO2 | P25791 | HOOK1 | Homo sapiens | Q9UJC3 | 25416956 | |
|
Intra
|
LMO2 | P25791 | MRFAP1L1 | Homo sapiens | Q96HT8 | 25416956 | |
|
Intra
|
LMO2 | P25791 | IHO1 | Homo sapiens | Q8IYA8 | 25416956 | |
|
Intra
|
LMO2 | P25791 | ROCK1 | Homo sapiens | Q13464 | 25416956 | |
|
Intra
|
LMO2 | P25791 | ROCK1 | Homo sapiens | Q13464 | 25416956 | |
|
Intra
|
LMO2 | P25791 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
LMO2 | P25791 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
LMO2 | P25791 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
LMO2 | P25791 | C1orf94 | Homo sapiens | Q6P1W5 | 25416956 |
LMO2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81528 | LMO2 Antibody (YA1273) | IHC-P | Human |
| HY-P81528A | LMO2 Antibody (YA1273)(PBS only) | IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Severe Combined Immunodeficiency, X-Linked |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Lymphoblastic Lymphoma |
|
|
| Leukemia |
|
|
| Severe Combined Immunodeficiency |
|
|
| Combined Immunodeficiency |
|
|
| Granulomatous Disease, Chronic, X-Linked |
|
|
| Adenosine Deaminase Deficiency |
|
|
| Precursor T-Cell Acute Lymphoblastic Leukemia |
|
|
| Phagocyte Bactericidal Dysfunction |
|
|
| Childhood T-Cell Acute Lymphoblastic Leukemia |
|
|
| Ureteral Lymphoma |
|
|
| Nodal Marginal Zone Lymphoma |
|
|
| High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit |
|
|
| Purine-Pyrimidine Metabolic Disorder |
|
|
| Chronic Granulomatous Disease |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Thrombocytopenia |
|
|
| Metachromatic Leukodystrophy |
|
|
| Leukemia, Acute Myeloid |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | LMO2 | RGD | RGD:1307101 |
| Mus musculus | LMO2 | MGD | MGI:102811 |
| Felis catus | LMO2 | VGNC | VGNC:82023 |
| Bos taurus | LMO2 | VGNC | VGNC:30934 |
| Macaca mulatta | LMO2 | VGNC | VGNC:74431 |
| Others | LMO2 | NCBI |