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Cat. No.: HY-117720

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OSU-2S

Name: OSU-2S
Brand: MedChemExpress
SKU: HY-117720
Availability: PreOrder

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1351056-65-9
화학식: C₂₁H₃₇NO₂
분자량:335.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

OSU-2S Chemical Structure

CAS No.: 1351056-65-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PKCδ

All PKC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	4.2 μM Compound: OSU-2S	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 28865276]
Hep 3B2	IC₅₀	2.8 μM Compound: OSU-2S	Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay	[PMID: 28865276]
HepG2	IC₅₀	2.3 μM Compound: OSU-2S	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 28865276]
HT-29	IC₅₀	2.7 μM Compound: OSU-2S	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 28865276]

In Vitro

OSU-2S (1.25, 2.5 µM; 48 h) decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201) (2.5, 5 µM)^[1].
OSU-2S/Sorafenib (1.25, 2.5 µM; 8 h) combinantion inhibits cell proliferative and migration^[1].
OSU-2S (0, 1, 2.5, 5 µM; 0-24 h) decreases the expression of PARP in a dose and time-dependent manner in Hep3B cells^[2].
OSU-2S (5 µM; 12, 24 h) induces apoptosis in Hep3B cells^[2].
OSU-2S (0-10 µM; 1 h) stimulates ROS production in a dose-dependent manner in Hep3B, Huh7, PLC-5 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Hep3B, Huh7, PLC-5, HepG2 cells
Concentration:

0-10 µM
Incubation Time:

48 h
Result:

Showed anti-proliferative effects with IC₅₀s of 2.53, 2.41, 3.96, 1.84 µM for Hep3B, Huh7, PLC-5, HepG2 cells, respectively.

Western Blot Analysis^[1]

Cell Line:

Hep3B cells
Concentration:

1.25, 2.5 µM combinated with sorafenib (2.5, 5 µM)
Incubation Time:

48 h
Result:

Decreased the expression of ERK1/2 phosphorylation, increased the expression of PKCδ (38 kDa) when sorafenib/OSU-2S combination.

In Vivo

OSU-2S (5, 10 mg/kg; i.p.; once daily for 42 days) suppresses the tumor growth in mouse^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD2F1 mice (Hep3B tumor xenograft models)^[2]
Dosage:

5, 10 mg/kg
Administration:

I.p.; once daily for 42 days
Result:

Exhibited a higher tumor-suppressive potency, achieving 80% reduction in bioluminescence at the end of treatment.

Chemical Information

CAS No. 1351056-65-9
분자량 335.52
화학식 C₂₁H₃₇NO₂
SMILES

CCC[C@@](CCC1=CC=C(OCCCCCC(C)C)C=C1)(N)CO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Int Immunopharmacol

Osthole alleviates neuropathic pain by suppressing astrocytes activation and associated inflammatory responses via the PKCδ/TRPV4 signaling pathway. [Abstract]

2025 Sep 10:165:115453. PMID: 40934539

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Omar HA, et al. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53. Front Pharmacol. 2016 Nov 30;7:463. [Content Brief]

[2]. Omar HA, et al. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 2011 Jun;53(6):1943-58. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References

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OSU-2S

Publications Citing Use of MedChemExpress (MCE) OSU-2S

All PKC Isoforms