2. Epigenetics TGF-beta/Smad Apoptosis
  3. PKC Apoptosis
  4. OSU-2S

OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity.

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OSU-2S Chemical Structure

OSU-2S Chemical Structure

CAS No. : 1351056-65-9

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OSU-2S Related Antibodies

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Description

OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity[1][2].

IC50 & Target[1]

PKCδ

 

In Vitro

OSU-2S (1.25, 2.5 µM; 48 h) decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201) (2.5, 5 µM)[1].
OSU-2S/Sorafenib (1.25, 2.5 µM; 8 h) combinantion inhibits cell proliferative and migration[1].
OSU-2S (0, 1, 2.5, 5 µM; 0-24 h) decreases the expression of PARP in a dose and time-dependent manner in Hep3B cells[2].
OSU-2S (5 µM; 12, 24 h) induces apoptosis in Hep3B cells[2].
OSU-2S (0-10 µM; 1 h) stimulates ROS production in a dose-dependent manner in Hep3B, Huh7, PLC-5 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OSU-2S Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Hep3B, Huh7, PLC-5, HepG2 cells
Concentration: 0-10 µM
Incubation Time: 48 h
Result: Showed anti-proliferative effects with IC50s of 2.53, 2.41, 3.96, 1.84 µM for Hep3B, Huh7, PLC-5, HepG2 cells, respectively.

Western Blot Analysis[1]

Cell Line: Hep3B cells
Concentration: 1.25, 2.5 µM combinated with sorafenib (2.5, 5 µM)
Incubation Time: 48 h
Result: Decreased the expression of ERK1/2 phosphorylation, increased the expression of PKCδ (38 kDa) when sorafenib/OSU-2S combination.
In Vivo

OSU-2S (5, 10 mg/kg; i.p.; once daily for 42 days) suppresses the tumor growth in mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD2F1 mice (Hep3B tumor xenograft models)[2]
Dosage: 5, 10 mg/kg
Administration: I.p.; once daily for 42 days
Result: Exhibited a higher tumor-suppressive potency, achieving 80% reduction in bioluminescence at the end of treatment.
Molecular Weight

335.52

Formula

C21H37NO2
CAS No.
SMILES

CCC[C@@](CCC1=CC=C(OCCCCCC(C)C)C=C1)(N)CO
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Purity & Documentation
References
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OSU-2S Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OSU-2S1351056-65-9PKCApoptosisProtein kinase Canti-proliferativeantimigrationanticancerHep3Bp-ERK1/2SorafenibROSapoptosisInhibitorinhibitorinhibit

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