1351056-65-9
Chemical Structure
OSU-2S
- CAS No.: 1351056-65-9
- Formula:C21H37NO2
- Molecular Weight:335.52
IUPAC Name: (S)-2-amino-2-(4-((6-methylheptyl)oxy)phenethyl)pentan-1-ol
InChIKey: MDUCYXCGWGNEMH-NRFANRHFSA-N
SMILES: CCC[C@@](CCC1=CC=C(OCCCCCC(C)C)C=C1)(N)CO
Biological Activity: OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity[1][2].
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OSU-2S | OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity. | |||||||||||||||||||||
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- [1]. Omar HA, et al. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53. Front Pharmacol. 2016 Nov 30;7:463. [Content Brief]
- [2]. Omar HA, et al. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 2011 Jun;53(6):1943-58. [Content Brief]
Keywords
