1. Metabolic Enzyme/Protease
    GPCR/G Protein
  2. Endogenous Metabolite
    Prostaglandin Receptor

p-Hydroxycinnamic acid (Synonyms: NSC 59260; NSC 674321; p-Coumaric acid; p-Cumaric acid)

Cat. No.: HY-N2391 Purity: 99.85%
Handling Instructions

p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.

For research use only. We do not sell to patients.

p-Hydroxycinnamic acid Chemical Structure

p-Hydroxycinnamic acid Chemical Structure

CAS No. : 7400-08-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 70 In-stock
Estimated Time of Arrival: December 31
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
500 mg USD 110 In-stock
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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.

IC50 & Target

IC50: 371 μM (thromboxane B2), 126 μM (prostaglandin E2)[1].

In Vitro

p-Hydroxycinnamic acid (p-Coumaric acid), is a ubiquitous plant metabolite with antioxidant and anti-inflammatory properties. p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55•2 (SE 4•01) % and 35•6 (SE 2•35) % relative to basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary haemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0916 mL 30.4581 mL 60.9162 mL
5 mM 1.2183 mL 6.0916 mL 12.1832 mL
10 mM 0.6092 mL 3.0458 mL 6.0916 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

164.16

Formula

C₉H₈O₃

CAS No.

7400-08-0

SMILES

O=C(O)/C=C/C1=CC=C(O)C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
p-Hydroxycinnamic acid
Cat. No.:
HY-N2391
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p-Hydroxycinnamic acid

Cat. No.: HY-N2391