1. MAPK/ERK Pathway
    Autophagy
  2. p38 MAPK
    Autophagy
  3. p38 MAPK-IN-1

p38 MAPK-IN-1 

Cat. No.: HY-12839 Purity: 98.09%
Handling Instructions

p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.

For research use only. We do not sell to patients.

p38 MAPK-IN-1 Chemical Structure

p38 MAPK-IN-1 Chemical Structure

CAS No. : 1006378-90-0

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5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

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Description

p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.

IC50 & Target[1]

p38 MAPK

68 nM (IC50)

In Vivo

p38 MAPK-IN-1 (Compound 4; 1 mg/kg for iv and 10 mg/kg for po) has a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for po in male wistar rats[1].
p38 MAPK-IN-1 dose-dependently inhibits TNFα production with an ED50 of 0.5 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male wistar rats[1]
Dosage: 10 mg/kg for po and 1 mg/kg for iv (Pharmacokinetic Analysis)
Administration: Po and iv
Result: Had a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for po.
Molecular Weight

349.35

Formula

C₂₁H₁₅F₂N₂O

CAS No.
SMILES

FC1=CC(F)=C(C2=CC=NC(C2=CC=[NH+]3[O-])=C3C4=C(C)C=CC=C4)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (23.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8625 mL 14.3123 mL 28.6246 mL
5 mM 0.5725 mL 2.8625 mL 5.7249 mL
10 mM 0.2862 mL 1.4312 mL 2.8625 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (2.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (2.38 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (2.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.91%

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Keywords:

p38 MAPK-IN-1p38 MAPKAutophagysustainedlevelslowclearancebioavailabilityInhibitorinhibitorinhibit

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p38 MAPK-IN-1
Cat. No.:
HY-12839
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