Proteasome β2c/i-IN-1
Proteasome β2c/i-IN-1 (compound 37) is a subunit-selective human proteasome β2c and β2i inhibitor .
For research use only. We do not sell to patients.
- CAS No.: 2322333-75-3
- Formula: C32H48N4O7
- Molecular Weight:600.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Raji | IC50 |
>100 μM
Compound: 39
|
Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human Raji cell lysates after 1 hr by competitive ABPP assay
Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human Raji cell lysates after 1 hr by competitive ABPP assay
|
[PMID: 30657666] |
| Raji | IC50 |
>100 μM
Compound: 39
|
Inhibition of 20S immunoproteasome beta 1 in human Raji cell lysates after 1 hr by competitive ABPP assay
Inhibition of 20S immunoproteasome beta 1 in human Raji cell lysates after 1 hr by competitive ABPP assay
|
[PMID: 30657666] |
| Raji | IC50 |
0.046 μM
Compound: 39
|
Inhibition of 20S immunoproteasome beta 5 in human Raji cell lysates after 1 hr by competitive ABPP assay
Inhibition of 20S immunoproteasome beta 5 in human Raji cell lysates after 1 hr by competitive ABPP assay
|
[PMID: 30657666] |
| Raji | IC50 |
0.057 μM
Compound: 39
|
Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assay
Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assay
|
[PMID: 30657666] |
| Raji | IC50 |
2.5 μM
Compound: 39
|
Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assay
Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assay
|
[PMID: 30657666] |
| Raji | IC50 |
5 μM
Compound: 39
|
Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assay
Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assay
|
[PMID: 30657666] |
Chemical Information
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CAS No. 2322333-75-3
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Molecular Weight 600.75
-
Formula C32H48N4O7
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SMILES
COC(C=C1)=CC=C1C[C@H](NC([C@H](C)NC(CN2CCOCC2)=O)=O)C(N[C@@H](CCC3CCCCC3)C([C@]4(CO4)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)