2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. PTERi

PTERi is a selective inhibitor of PTER with selectivity towards HDACs. PTERi increases the level of N-acetyltaurine in both lean and obese mice, and reduces food intake in obese mice. PTERi can be used in the research of obesity.

For research use only. We do not sell to patients.

PTERi

PTERi Chemical Structure

CAS No. : 3114432-21-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

PTERi Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

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Description

PTERi is a selective inhibitor of PTER with selectivity towards HDACs. PTERi increases the level of N-acetyltaurine in both lean and obese mice, and reduces food intake in obese mice. PTERi can be used in the research of obesity[1].

In Vitro

PTERi (Compound 41) (1 h) potently and selectively inhibits recombinant mouse PTER-mediated N-acetyltaurine hydrolysis, with over 250-fold selectivity over HDAC enzymes[1].
PTERi exhibits only weak inhibitory activity against HDACs 1-11 and SIRTs 1-4, and shows high selectivity for PTER[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTERi Related Antibodies
In Vivo

PTERi (100 mg/kg; i.p.; daily/single administration) dose-dependently increases plasma N-acetyltaurine levels, reduces food intake and body weight, decreases fat mass, enhances the weight loss efficacy of Semaglutide (HY-114118), and prevents body weight rebound after discontinuation of GLP-1R agonists in obese mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male; diet-induced obese)[1]
Dosage: 100 mg/kg (acute studies; 1 week; 3 weeks; 27 days; 10 days rebound study)
Administration: i.p.; daily (chronic/rebound/combination studies); single dose (acute studies)
Result: Induced a dose-dependent increase in plasma N-acetyltaurine levels in lean mice, and increased levels up to 1 hour post-injection in lean mice and 2 hours post-injection in obese mice.
Reduced food intake at 6 and 18 hours post-single injection in obese mice.
Decreased cumulative food intake and reduced body weight over 8 days and 3 weeks of daily treatment in obese mice.
Resulted in loss of adipose mass with no changes in liver, kidney, or heart mass after 27 days of daily treatment.
When combined with semaglutide, further reduced cumulative food intake and lowered body weight compared to vehicle-treated obese mice over 1 week.
Prevented weight regain in obese mice switched from semaglutide to PTER-IN-1 after 15 days of semaglutide treatment; these mice maintained weight loss at a level comparable to mice continuing semaglutide therapy, whereas mice switched to vehicle gained weight.
Molecular Weight

372.37

Formula

C19H20N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCOCCOCCN1C(C2=C3C(C1=O)=CC=CC3=CC=C2)=O)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (67.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6855 mL 13.4275 mL 26.8550 mL
5 mM 0.5371 mL 2.6855 mL 5.3710 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6855 mL 13.4275 mL 26.8550 mL 67.1375 mL
5 mM 0.5371 mL 2.6855 mL 5.3710 mL 13.4275 mL
10 mM 0.2686 mL 1.3428 mL 2.6855 mL 6.7138 mL
15 mM 0.1790 mL 0.8952 mL 1.7903 mL 4.4758 mL
20 mM 0.1343 mL 0.6714 mL 1.3428 mL 3.3569 mL
25 mM 0.1074 mL 0.5371 mL 1.0742 mL 2.6855 mL
30 mM 0.0895 mL 0.4476 mL 0.8952 mL 2.2379 mL
40 mM 0.0671 mL 0.3357 mL 0.6714 mL 1.6784 mL
50 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.3428 mL
60 mM 0.0448 mL 0.2238 mL 0.4476 mL 1.1190 mL
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PTERi Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTERi3114432-21-9HDACHistone deacetylasesPTER-selective inhibitorobesityC57BL/6J mice
Inhibitorinhibitorinhibit

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