Glucagon-like Peptide 2

  • Trends Endocrinol Metab. 1999 May;10(4):153-156. doi: 10.1016/s1043-2760(98)00136-2.
DJ Drucker  1
Affiliations
  • 1. Banting and Best Diabetes Center, The Toronto Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2C4.
PMID: 10322410 DOI: 10.1016/s1043-2760(98)00136-2
Abstract

Glucagon-like peptide 2 (GLP-2) is secreted in a nutrient-dependent manner from enteroendocrine cells throughout the gastrointestinal tract and is trophic to the intestinal epithelial mucosa. GLP-2 acts via stimulation of crypt cell proliferation and inhibition of cell death. GLP-2 also stimulates intestinal glucose transport, decreases mucosal permeability, and shows therapeutic efficacy in experimental models of short bowel syndrome and both small and large bowel inflammation.