Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities

  • Phytochemistry. 2000 Nov;55(6):643-51. doi: 10.1016/s0031-9422(00)00248-x.
D M Tomazela  1 ,  M T Pupo ,  E A Passador ,  M F da Silva ,  P C Vieira ,  J B Fernandes ,  E R Fo ,  G Oliva ,  J R Pirani
Affiliations
  • 1. Departamento de Química, Universidade Federal de São Carlos, SP, Brazil.
PMID: 11130676 DOI: 10.1016/s0031-9422(00)00248-x
Abstract

The fruits of Neoraptua magnifica var. magnifica afforded three new flavonoids: 2'-hydroxy-4,4',-dimethoxy-5',6'-(2'',2''-dimethylpyrano)chalcone, 2'-hydroxy-3,4,4'-trimethoxy-5',6'-(2'',2''-dimethylpyrano)chalcone, and 3',4'-methylenedioxy-5,7-dimethoxyflavone which were identified on the basis of spectroscopic methods. The known Flavonoids 2'-hydroxy-3,4,4',5-tetramethoxy-5',6'-(2'',2''-dimethylpyrano)chalcone, 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone, 3',4'-methylenedioxy-5,6,7-trimethoxyflavone, 3',4'-methylenedioxy-5',5,6,7-tetramethoxyflavone, 3',4',5',5,7-pentamethoxyflavanone and 3',4',5'5,7-pentamethoxyflavone were also identified. The latter flavone was the most active as glyceraldehyde-3-phosphate dehydrogenase-inhibitor.

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