kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from polyozellus multiplex

  • J Antibiot (Tokyo). 2002 Jul;55(7):623-8. doi: 10.7164/antibiotics.55.623.
Sang-In Kim  1 ,  In-Hye Park ,  Kyung-Sik Song
Affiliations
  • 1. Division of Applied Biology and Chemistry, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, Korea.
PMID: 12243451 DOI: 10.7164/antibiotics.55.623
Abstract

Two new benzofurans, 5,6-dihydroxybenzofuran-2,3-dicarboxylic acid dimethyl ester (kynapcin-13) and 5,6,5',6'-tetrahydroxy[3,3']bibenzofuranyl-2,2'-dicarboxylic acid 2'-methyl ester (kynapcin-28) were isolated from Polyozellus multiplex, and shown to non-competitively inhibit prolyl endopeptidase (PEP), with the IC50 values of 76.80 and 0.98 microM, respectively. Kynapcin-13 and -28 were less inhibitory to Other serine proteases such as chymotrypsin, trypsin, and Elastase.

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