Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation

  • Mol Cell. 2006 May 5;22(3):317-27. doi: 10.1016/j.molcel.2006.04.007.
Xuan Liu  1 ,  Wei Huang ,  Chufang Li ,  Ping Li ,  Jing Yuan ,  Xiaorong Li ,  Xiao-Bo Qiu ,  Qingjun Ma ,  Cheng Cao
Affiliations
  • 1. Beijing Institute of Biotechnology, Beijing 100850, China.
PMID: 16678104 DOI: 10.1016/j.molcel.2006.04.007
Abstract

Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine Kinases associate with and phosphorylate the Proteasome PSMA7 (alpha4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a Proteasome subunit as an important cellular regulatory control.