Novel bile acids from bear bile powder and bile of geese

  • Chem Pharm Bull (Tokyo). 2009 May;57(5):528-31. doi: 10.1248/cpb.57.528.
Dan Bi  1 ,  Xing-Yun Chai ,  Yue-Lin Song ,  Yu Lei ,  Peng-Fei Tu
Affiliations
  • 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.
PMID: 19420790 DOI: 10.1248/cpb.57.528
Abstract

Two new bile acids, tauroselocholic acid (1) and tauroansocholic acid (2), a new natural bile acid, cygnocholic acid (3) were respectively isolated from bear bile powder Selenaretos thibetanus CUVIER and bile of geese Anser anser domesticus, together with seven known compounds. By spectrum analysis of MS, 1D and 2D NMR, the structures of the new compounds were elucidated as 3alpha,7alpha,9alpha-trihydroxy-5beta-cholan-24-oic acid N-[2-sulfoethyl] amide (1), 3alpha,5,7alpha-trihydroxy-5beta-cholan-24-oic acid N-[2-sulfoethyl] amide (2) and 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid (3).

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