New clerodane diterpenoids from Casearia sylvestris

  • Fitoterapia. 2009 Oct;80(7):404-7. doi: 10.1016/j.fitote.2009.05.013.
Wei Wang  1 ,  Zulfiqar Ali ,  Xing-Cong Li ,  Troy A Smillie ,  De-An Guo ,  Ikhlas A Khan
Affiliations
  • 1. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, Oxford, MS 38677, USA.
PMID: 19465090 DOI: 10.1016/j.fitote.2009.05.013
Abstract

Two new clerodane Diterpenoids 2 beta-methoxy-cleroda-3,13-dien-18-carboxy-15,16-olide (1) and 15 xi-methoxy-cleroda-3,12-dien-18-carboxy-15,16-olide (2) and one new nitrogen-containing clerodane diterpenoid 15-oxo-echinophyllin A (3), along with six known compounds, namely, echinophyllin A, (-)-patagonic acid, tyrosol, oplopanone, 4-hydroxy-4-methyl-2-[(1R)-1-(1-methylethyl)-4-oxopentyl]-2-cyclohexen-1-one and 1 beta,6 alpha-dihydroxy-eudesman-4(15)-ene were isolated from the leaves of Casearia sylvestris. Their structures were determined by extensive NMR techniques.

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