Tandem facial amphiphiles for membrane protein stabilization

  • J Am Chem Soc. 2010 Dec 1;132(47):16750-2. doi: 10.1021/ja1072959.
Pil Seok Chae  1 ,  Kamil Gotfryd ,  Jennifer Pacyna ,  Larry J W Miercke ,  Søren G F Rasmussen ,  Rebecca A Robbins ,  Rohini R Rana ,  Claus J Loland ,  Brian Kobilka ,  Robert Stroud ,  Bernadette Byrne ,  Ulrik Gether ,  Samuel H Gellman
Affiliations
  • 1. Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States.
PMID: 21049926 DOI: 10.1021/ja1072959
Abstract

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.

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