Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery

  • Adv Mater. 2012 Jan 3;24(1):64-70, 2. doi: 10.1002/adma.201103574.
Edward A Phelps  1 ,  Nduka O Enemchukwu ,  Vincent F Fiore ,  Jay C Sy ,  Niren Murthy ,  Todd A Sulchek ,  Thomas H Barker ,  Andrés J García
Affiliations
  • 1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA.
PMID: 22174081 DOI: 10.1002/adma.201103574
Abstract

Engineered polyethylene glycol-maleimide matrices for regenerative medicine exhibit improved reaction efficiency and wider range of Young’s moduli by utilizing maleimide cross-linking chemistry. This hydrogel chemistry is advantageous for cell delivery due to the mild reaction that occurs rapidly enough for in situ delivery, while easily lending itself to “plug-and-play” design variations such as incorporation of enzyme-cleavable cross-links and cell-adhesion peptides.

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