Alkaloids isolated from the lateral root of Aconitum carmichaelii

  • Molecules. 2012 Aug 20;17(8):9939-46. doi: 10.3390/molecules17089939.
Liang Xiong  1 ,  Cheng Peng ,  Xiao-Fang Xie ,  Li Guo ,  Cheng-Jun He ,  Zhao Geng ,  Feng Wan ,  Ou Dai ,  Qin-Mei Zhou
Affiliations
  • 1. State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China.
PMID: 22907155 DOI: 10.3390/molecules17089939
Abstract

Two new Alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole Alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate Antibacterial activity.

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