Sesquiterpenoids from the mangrove-derived endophytic fungus Diaporthe sp

  • J Nat Prod. 2012 Oct 26;75(10):1744-9. doi: 10.1021/np3004112.
Le Yun Zang  1 ,  Wei Wei ,  Ye Guo ,  Ting Wang ,  Rui Hua Jiao ,  Seik Weng Ng ,  Ren Xiang Tan ,  Hui Ming Ge
Affiliations
  • 1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Lifescience, Nanjing University, Nanjing 210093, People's Republic of China.
PMID: 23006147 DOI: 10.1021/np3004112
Abstract

A new sesquiterpenoid, diaporol A (1), possessing a unique tricyclic lactone framework, eight new drimane sesquiterpenoids, diaporols B-I (2-9), and the known compounds 10 and 11 were isolated from a culture of the mangrove-derived endophyte Diaporthe sp. The absolute configurations of 1-5 were determined by low-temperature (100 K) single-crystal X-ray diffraction with Cu Kα radiation. The compounds were evaluated for cytotoxic activity; however, no compound showed significant cytotoxicity against the tested cell lines at a concentration of 20 μM.

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