Williams-Beuren Syndrome and Burkitt Leukemia
- J Pediatr Hematol Oncol. 2013 Jan;35(1):e30-2. doi: 10.1097/MPH.0b013e318270672f.
Affiliations
- 1. Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. [email protected]
PMID: 23018576
DOI: 10.1097/MPH.0b013e318270672f
Abstract
Williams-Beuren Syndrome (WBS) is associated with constitutional deletion of 7q11.23, which includes the elastin gene. Cytogenetic abnormalities of chromosome 7 are frequently described in several human malignancies. Here, we report Burkitt Leukemia in an 8-year-old boy with WBS. In this patient, constitutional deletion of chromosome 7q11.23 including BCL7B was confirmed. WBS may predispose patients to Burkitt Leukemia.