Chemical constituents of Lobelia chinensis

  • Fitoterapia. 2014 Mar:93:168-74. doi: 10.1016/j.fitote.2014.01.007.
Shuang Yang  1 ,  Tao Shen  1 ,  Lijuan Zhao  1 ,  Chao Li  1 ,  Yao Zhang  1 ,  Hongxiang Lou  1 ,  Dongmei Ren  2
Affiliations
  • 1. Department of Natural Products Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
  • 2. Department of Natural Products Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China. Electronic address: [email protected].
PMID: 24444893 DOI: 10.1016/j.fitote.2014.01.007
Abstract

Three new 2, 6-disubstituted Piperidine Alkaloids (1-3), one new polyacetylene (8), together with eight known compounds (4-7, 9-12) were isolated from the whole Plants of Lobelia chinensis. Their structures were elucidated on the basis of spectroscopic data interpretation. The absolute configuration of 1 was established by a convenient Mosher ester procedure in which the sample was treated with MTPA chlorides in deuterated pyridine directly in NMR tube. Cytotoxicities of compounds 1-12 were tested against two human lung Cancer cell lines, NCI-H292 and MSTO-211H. Compounds 8 and 9 exhibited moderate cytotoxic activity against the two Cancer cell lines with the IC50 values in the range of 9.31-12.36 μM.

Keywords
Lobelia chinensis; Mosher ester procedure; Piperidine alkaloids; Polyacetylene.
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