Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

  • Bioorg Med Chem Lett. 2014 Sep 1;24(17):4095-8. doi: 10.1016/j.bmcl.2014.07.066.
Yehee Lee  1 ,  Weihong Wang  1 ,  Hiyoung Kim  1 ,  Awadut G Giri  1 ,  Dong Hwan Won  1 ,  Dongyup Hahn  1 ,  Kyung Ryul Baek  1 ,  Jihye Lee  1 ,  Inho Yang  1 ,  Hyukjae Choi  2 ,  Sang-Jip Nam  3 ,  Heonjoong Kang  4
Affiliations
  • 1. Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Republic of Korea.
  • 2. College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Republic of Korea.
  • 3. Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: [email protected].
  • 4. Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Republic of Korea; Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Republic of Korea. Electronic address: [email protected].
PMID: 25124114 DOI: 10.1016/j.bmcl.2014.07.066
Abstract

Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine Sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas Cancer cells (IC50=11.4 μM).

Keywords
Cytotoxicity; Phorbaketals; Phorbas sp..