Salvianolic acid Y: a new protector of PC12 cells against hydrogen peroxide-induced injury from Salvia officinalis

  • Molecules. 2015 Jan 6;20(1):683-92. doi: 10.3390/molecules20010683.
Jun Gong  1 ,  Aichun Ju  2 ,  Dazheng Zhou  3 ,  Dekun Li  4 ,  Wei Zhou  5 ,  Wanli Geng  6 ,  Bing Li  7 ,  Li Li  8 ,  Yanjie Liu  9 ,  Ying He  10 ,  Meizhen Song  11 ,  Yunhua Wang  12 ,  Zhengliang Ye  13 ,  Ruichao Lin  14
Affiliations
  • 1. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 2. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 3. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 4. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 5. Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 6. Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 7. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 8. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 9. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 10. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 11. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 12. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 13. Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. [email protected].
  • 14. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100050, China. [email protected].
PMID: 25569522 DOI: 10.3390/molecules20010683
Abstract

Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR (1H-1H COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The biosynthesis pathway of salvianolic acid B and salvianolic acid Y (TSL 1) was proposed based on structural analysis. The protection of PC12 cells from injury induced by H2O2 was assessed in vitro using a cell viability assay. Salvianolic acid Y (TSL 1) protected cells from injury by 54.2%, which was significantly higher than salvianolic acid B (35.2%).

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