New cytotoxic sesquiterpenoids from Siegesbeckia glabrescens

  • Molecules. 2015 Feb 10;20(2):2850-6. doi: 10.3390/molecules20022850.
Qian Wu  1 ,  Hua Li  2 ,  So Yoon Lee  3 ,  Hwa Jin Lee  4 ,  Jae-Ha Ryu  5
Affiliations
  • 1. Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. [email protected].
  • 2. Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. [email protected].
  • 3. Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. [email protected].
  • 4. Department of Natural Medicine Resources, Semyung University, Chungbuk 390-711, Korea. [email protected].
  • 5. Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. [email protected].
PMID: 25690283 DOI: 10.3390/molecules20022850
Abstract

Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known Sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human Cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target Cancer cells with IC50 values in the range of 0.9-33.3 μM.

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