A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides

  • Bioorg Med Chem Lett. 2016 Apr 1;26(7):1651-4. doi: 10.1016/j.bmcl.2016.02.069.
Ke Wang  1 ,  Frédéric Friscourt  2 ,  Chaofeng Dai  1 ,  Lifang Wang  1 ,  Yueqin Zheng  1 ,  Geert-Jan Boons  2 ,  Siming Wang  1 ,  Binghe Wang  3
Affiliations
  • 1. Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA.
  • 2. Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
  • 3. Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302-3965, USA. Electronic address: [email protected].
PMID: 26944613 DOI: 10.1016/j.bmcl.2016.02.069
Abstract

Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to Other common anions with good sensitivity and detection limit of 10μM.

Keywords
Click chemistry; Fluorescent detection; Quantitative analysis; Sodium azide.
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