Bioactive Coumarins from the Stems of Clausena emarginata

  • Chem Biodivers. 2016 Sep;13(9):1178-1185. doi: 10.1002/cbdv.201500519.
Guo-Qing Ouyang  1 ,  Chuang-Jun Li  1 ,  Jing-Zhi Yang  1 ,  Li Li  1 ,  Xiu-Yun Song  1 ,  Yi-Na Jiang  1 ,  Nai-Hong Chen  1 ,  Jie Ma  2 ,  Dong-Ming Zhang  3
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China.
  • 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China. [email protected].
  • 3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China. [email protected].
PMID: 27450780 DOI: 10.1002/cbdv.201500519
Abstract

Five new Coumarins, clauemarmarins I - M (1 - 4), together with 10 known analogs (5 - 14), were isolated from the stems of Clausena emarginata. Compounds 8 - 13 were obtained from this plant for the first time. Their structures were established and elucidated by comprehensive analysis of spectroscopic data. The absolute configurations of 1 - 4 were further determined by their electronic circular dichroism spectroscopy. Compounds 5, 7, 12, and 14 exhibited inhibitory effects on LPS-induced NO production. Compounds 5 - 7 showed selective neuroprotective effects in Aβ25 - 35 model at 10 μm.

Keywords
Clauemarmarins; Clausena emarginata; Inhibitory effects; Neuroprotective effects; Stems.
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