Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils

  • Fitoterapia. 2017 Mar:117:16-21. doi: 10.1016/j.fitote.2016.12.008.
Lin-Yang Cheng  1 ,  Hsiang-Ruei Liao  2 ,  Li-Chai Chen  3 ,  Shih-Wei Wang  4 ,  Yueh-Hsiung Kuo  5 ,  Mei-Ing Chung  1 ,  Jih-Jung Chen  6
Affiliations
  • 1. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
  • 2. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
  • 3. Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan; Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan.
  • 4. Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan.
  • 5. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan; Department of Biotechnology, Asia University, Taichung 41354, Taiwan.
  • 6. Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan. Electronic address: [email protected].
PMID: 28012920 DOI: 10.1016/j.fitote.2016.12.008
Abstract

Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3-20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 11-hydroxy-2-O-methylhibiscolactone A (1), isohemigossylic acid lactone-7-methyl ether (4), gmelofuran (6), and 5-hydroxyauranetin (8) exhibited inhibition (IC50≤28.84μM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).

Keywords
Anti-inflammatory activity; Bombacaceae; Naphthofuranone; Pachira aquatica; Structure elucidation.
Products