Structures and antipathogenic fungi activities of flavonoids from pathogen-infected Astragalus adsurgens

  • Nat Prod Res. 2019 Mar;33(6):822-826. doi: 10.1080/14786419.2017.1413560.
Ya Li  1 ,  Wenjun Wei  1 ,  Jiwen Zhang  2 ,  Guangda Li  1 ,  Kun Gao  1
Affiliations
  • 1. a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou , People's Republic of China.
  • 2. b Key Laboratory of Botanical Pesticide R&D in Shaanxi Province , Northwest A&F University , Yangling , People's Republic of China.
PMID: 29262733 DOI: 10.1080/14786419.2017.1413560
Abstract

Healthy Astragalus adsurgens is a highly palatable forage widely cultivated in arid areas of north China, while pathogen- (Embellisia asttrgali ) infected A. adsurgens is poisonous forage and often causes disastrous livestock losses. A phytochemical investigation was carried out on the E. asttrgali-infected A. adsurgens; as a result, a new compound, (2R, 3S)-7,4'-dimethoxy-2'-hydroxyflavanol (1), together with nine known Flavonoids was obtained. It was found that the content of most of these compounds in E. asttrgali-infected A. adsurgens was higher than that in healthy A. adsurgens. Moreover, compounds 2 and 3 exhibited weak inhibitory activity against Fusarium graminearum and E. asttrgali with EC50 over 100 μg/mL, and showed moderate inhibitory activity against Bipolaris sorokinianum with EC50 of 39.1 and 95.0 μg/mL. Compounds 1-4 exhibited a high degree of inhibitory activity against Curvularia lunata, with 21.73, 43.93, 45.02 and 44.51% inhibition ratio at concentration of 50 μg/mL.

Keywords
antipathogenic fungi activity; flavonoids; pathogenic infection.
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