New pyrazinoquinazoline alkaloids Isolated from a culture of Stenotrophomonas maltophilia QB-77

  • Nat Prod Res. 2019 May;33(9):1387-1391. doi: 10.1080/14786419.2018.1475381.
Sheng-Yan Qian  1  2 ,  Cai-Ling Yang  1 ,  Afsar Khan  3 ,  Rong-Xiang Chen  4 ,  Ming-Song Wu  1 ,  Li Tuo  4 ,  Qian Wang  2 ,  Jian-Guo Liu  1 ,  Gui-Guang Cheng  5
Affiliations
  • 1. a Special Key Laboratory of Oral Disease Research , High Education Institution in Guizhou Province, Zunyi Medical University , Zunyi , P. R. China.
  • 2. c Special Key Laboratory of Microbial Resources and Drug Development , High Education Institution in Guizhou Province, Zunyi Medical University , Zunyi , P. R. China.
  • 3. d Department of Chemistry , COMSATS Institute of Information Technology , Abbottabad , Pakistan.
  • 4. e Zunyi Engineering Technology Research Center of Physical and Chemical , Zunyi Medical University , Zunyi , P. R. China.
  • 5. b Yunnan Institute of Food Safety , Kunming University of Science and Technology , Kunming , P. R. China.
PMID: 29770716 DOI: 10.1080/14786419.2018.1475381
Abstract

Two new pyrazinoquinazoline Alkaloids, epi-fiscalin D (1) and epi-fiscalin E (2), as well as three known analogues, norquinadoline A (3), quinadoline A (4), and fiscalin C (5), were isolated from ethyl acetate extract of the fermentation broth of Stentrophomonas maltophilia QB-77. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis including UV, HRESIMS, and 1D and 2D NMR experiments. All the isolated compounds were tested for their in vitro cytotoxicity against five human Cancer cell lines (SMMC-7721, MCF-7, HL-60, SW480, and A-549) and Antibacterial activities against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus.

Keywords
QB-77; antibacterial activity; cytotoxic activity; pyrazinoquinazoline alkaloids.
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