Hydroquinone and terpene glucosides from Leontopodium leontopodioides and their lipase inhibitory activity

  • Fitoterapia. 2018 Oct:130:89-93. doi: 10.1016/j.fitote.2018.08.010.
Ping Gou  1 ,  Yangyang Xiao  2 ,  Ling Lv  2 ,  Haihui Xie  3
Affiliations
  • 1. College of Life Science and Technology, Xinjiang University, Urumqi 830046, China. Electronic address: [email protected].
  • 2. Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • 3. Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: [email protected].
PMID: 30145331 DOI: 10.1016/j.fitote.2018.08.010
Abstract

Three new glucosides of hydroquinone, monoterpene, and megastigmane, benzyl 2,5-dihydroxybenzoate 5-O-β-d-glucopyranoside (isotrichocarpin, 1), (2S,3R)-3,7-dimethyl-6-octene-1,2,3-triol 2-O-β-d-glucopyranoside (leontopodioside D, 4), and (6R,7R,8R,9S)-6,9-epoxy-7,8-dihydroxymegastigman-4-en-3-one 8-O-β-d-glucopyranoside (leontopodioside E, 7) were isolated from the whole herbs of Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae), along with nebrodenside A (2), pungenin (3), betulalbuside A (5), geranyl O-β-d-glucopyranoside (6), and 3β-hydroxy-β-ionone 3-O-β-d-glucopyranoside (8). Their structure were determined by spectroscopic and chemical methods. All the known compounds were reported from this species for the first time. Compounds 2-6 showed potent in vitro pancreatic Lipase inhibitory activity, suggesting their participation in the reductive effect of the herbs on triglyceride absorption.

Keywords
Hydroquinone glucoside; Leontopodium leontopodioides; Megastigmane glucoside; Monoterpene glucoside; Pancreatic lipase inhibition.
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