Identification Of Potential Cytotoxic Inhibitors From Physalis Minima

  • Nat Prod Res. 2021 Jun;35(12):2082-2085. doi: 10.1080/14786419.2019.1650360.
Viet Cuong Le Canh  1 ,  Vinh Le Ba  2  3 ,  Pham Thi Hai Yen  1  4 ,  Lien Le Thi  1  4 ,  Pham Thi Thuy Hoai  1 ,  Ton That Huu Dat  1 ,  Do Thi Thao  5 ,  Long Giang Bach  6 ,  Young Ho Kim  3 ,  Hoang Le Tuan Anh  1  4
Affiliations
  • 1. Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), 321 Huynh Thuc Khang street, Hue city Vietnam.
  • 2. Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet street, Hanoi city, Vietnam.
  • 3. College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea.
  • 4. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet street, Hanoi city, Vietnam.
  • 5. Institute of Biotechnology, VAST, 18 Hoang Quoc Viet street, Hanoi city, Vietnam.
  • 6. Nguyen Tat Thanh University, 300A Nguyen Tat Thanh street, Ho Chi Minh city, Vietnam.
PMID: 31402707 DOI: 10.1080/14786419.2019.1650360
Abstract

A phytochemical investigation of Physalis minima led to the isolation of six withanolides, including withanolide E (1), withaperuvin C (2), 4β-hydroxywithanolide E (3), 28-hydroxywithaperuvin C (4), physaperuvin G (5), and 4-deoxywithaperuvin (6). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 Cancer cell lines. As the obtained results, compounds 1 and 3 displayed the strongest cytotoxicity against HepG2, SK-LU-1, and MCF7 cell lines with IC50 value ranging from 0.051 ± 0.004 to 0.86 ± 0.09 μg/mL.

Keywords
Physalis minima; anti-cancer; cytotoxic activity; withanolide.
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